输血及非输血型慢性HCV感染的临床特征分析  

The analysis of clinical characteristics of transfusion and non transfusion chronic hepatitis C virus infection

作　　者：王菲[1] 胡静[1] 王一明[2] WANG Fei;HU Jing;WANG Yi-ming(Infection Control Office,Macheng people′s Hospital,Hubei 43830,China)

机构地区：[1]麻城市人民医院感控办,湖北438300 [2]麻城市人民医院感染科,湖北438300

出　　处：《肝脏》2020年第9期946-947,971,共3页Chinese Hepatology

基　　金：湖北省自然科学基金项目(2017CBD0241)。

摘　　要：目的研究输血及非输血型慢性丙型肝炎病毒(HCV)感染的临床特点。方法根据平行对照试验原则,回顾性分析本院84例HCV感染患者临床资料,其中经输血途径感染者42例,为观察组,另42例为非输血途径HCV感染,为对照组。比较两组基本人口学资料和病理特点相关指标,记录输血与非输血型HCV感染患者临床特点。结果观察组患者年龄显著高于对照组,差异有统计学意义(P<0.05)。两组患者性别、体质指数、职业及文化程度无显著性差异(P>0.05)。观察组患者病程长于对照组,差异有统计学意义(P<0.05),两组HCV基因型分布差异有统计学意义(P<0.05)。两组HCV病毒载量无显著性差异(P>0.05)。结论不同途径HCV感染患者基因型分布具有显著差异,经输血途径感染者病程较长,年龄较大。Objective To study the clinical characteristics of transfusion and non transfusion chronic hepatitis C virus(HCV)infection.Methods The clinical dataes of 84 patients with HCV infection were analyzed retrospectively,which accorded to the principle of parallel control trial.There were 42 cases were infected by blood transfusion among them,which was the observation group.The other 42 cases were non blood transfusion HCV infection,which was the control group.The basic demographic dataes and pathological characteristics of the two groups were compared,and the clinical characteristics of the patients with HCV infection were recorded.Results The age of patients in the observation group was significantly higher than that in the control group,the difference was statistically significant(P<0.05).There were no significant difference in gender,BMI,occupation and education between the two groups(P>0.05).The course of disease in the observation group was longer than that in the control group,the difference was statistically significant(P<0.05).There was significant difference in the distribution of HCV genotypes between the two groups(P<0.05).There was no significant difference in HCV load between the two groups(P>0.05).Conclusion There are significant differences in genotype distribution among patients with different routes of HCV infection.The patients who infected by blood transfusion has longer course of disease and the age is older.

关 键 词：输血型慢性丙型肝炎 临床特征 感染 

分 类 号：R512.63[医药卫生—内科学]