泡沫细胞在动脉粥样硬化形成过程中的作用研究进展  

Research progress of foam cell in atherogenesis

作　　者：刘子歌 刘洋[1] 宋国瑞 张晨[1] 陈德胜[2] 郭凤英[3] 李燕[3] LIU Zige;LIU Yang;SONG Guorui(Ningxia Medical University,Yinchuan 750004)

机构地区：[1]宁夏医科大学,银川750004 [2]宁夏医科大学总医院骨科,银川750004 [3]宁夏医科大学基础医学院,银川750004

出　　处：《陕西医学杂志》2020年第10期1363-1366,F0003,共5页Shaanxi Medical Journal

基　　金：国家自然科学基金资助项目(81760405,81760395,81560364);宁夏回族自治区自然科学基金资助重点项目(2018AAC02013);宁夏医科大学校级课题重点项目(XZ2018014)。

摘　　要：动脉粥样硬化(AS)的形成是一个复杂的过程,不仅涉及免疫系统,还涉及血管壁的驻留细胞、遗传因素和脂质代谢的变化。动脉粥样硬化的发病机制目前仍未彻底明确。近年来国内外越来越多的研究表明,血脂代谢异常和氧化炎症等状态下导致的动脉内膜下泡沫细胞的形成和聚集,是动脉粥样硬化斑块形成的中心环节。同时,泡沫细胞分泌大量的细胞因子、趋化因子、蛋白酶以及其他炎症介质,会进一步促进斑块的局部炎性反应。本文将重点介绍泡沫细胞的形成以及泡沫细胞在动脉粥样硬化病变形成过程中的关键作用,从而为临床提供更加有效的预防动脉粥样硬化的方法。Atherogenesis is a more complex process involving not only the immune system,but also resident cells of the vessel wall,genetic factors,and changes in lipid metabolism.The pathogenesis of atherosclerosis is still unclear.However,recent works showed that the formation and aggregation of foam cells under the intima of the artery caused by abnormal metabolism of blood lipids and oxidative inflammation plays an important role in the formation of atherosclerosis.At the same time,foam cells secrete a large number of cytokines,chemokines,proteases and other inflammatory mediators,which will further promote the local inflammatory response of plaques.This article will focus on the formation and the key role of foam cells in the formation of atherosclerotic lesions,so as to provide more effective ways to prevent atherosclerosis in clinical practice.

关 键 词：动脉粥样硬化 泡沫细胞 胆固醇代谢 修饰型低密度脂蛋白 细胞因子 炎症介质 

分 类 号：R543.5[医药卫生—心血管疾病]