中国成年人静坐时间与2型糖尿病发病关系的前瞻性队列研究  

Relationship between sedentary time and incidence of type 2 diabetes in adults in China: a prospective cohort study

作　　者：从祥丰 刘少博 徐婷玲 王文绢[1] 马吉祥[2] 陈波[1] 李剑虹[1] Cong Xiangfeng;Liu Shaobo;Xu Tingling;Wang Wenjuan;Ma Jixiang;Chen Bo;Li Jianhong(National Center for Ch ronic and Non-communicable Disease Control and Prevention,Ch inese Center for Disease Control and Prevention,Beijing 100050,China;Office of Non-communicable Diseases and Ageing Health Management,Chinese Center for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]中国疾病预防控制中心慢性非传染性疾病预防控制中心,北京100050 [2]中国疾病预防控制中心慢病和老龄健康管理处,北京102206

出　　处：《中华流行病学杂志》2020年第9期1465-1470,共6页Chinese Journal of Epidemiology

基　　金：国家重点研发计划(2018YFC1313904)。

摘　　要：目的探讨我国成年人静坐时间与2型糖尿病发病的关系。方法将2010年中国慢性病及其危险因素监测数据作为基线数据。从2010年监测点中选取8个省,每个省选择2个监测点(城市和农村各1个)作为随访点,排除基线2型糖尿病患者,共8625人进入随访队列,2016-2017年进行随访调查,共随访到5991人。采用Cox比例风险回归模型分析静坐时间与2型糖尿病发病的关系,并按性别、地区、城乡等不同特征进行亚组分析。结果根据入选标准共纳入5782名研究对象,平均随访6.4年(36927.0人年),随访期间共观察到2型糖尿病发病事件592例,2型糖尿病发病密度为16.0/千人年。多因素Cox回归分析结果显示,在调整了相关混杂因素之后,与静坐时间0.0~h/d者相比,静坐时间>6.0 h/d者糖尿病发病风险增加33%(HR=1.33,95%CI:1.05~1.68)。亚组分析显示结果和全人群结果略有不同,只在男性、吸烟、中心性肥胖、超重/肥胖、有糖尿病家族史、农村、东部和中部地区人群中发现,静坐时间过长与糖尿病发病风险有统计学关联。结论静坐时间过长可增加2型糖尿病发病风险。应加强生活方式干预,减少成年人静坐时间,尤其是每日静坐时间>6.0 h的人群。Objective To explore the relationship between sedentary time and the incidence of type 2 diabetes in adults in China.Methods Data collected from the Chinese Chronic Disease and Risk Factor Surveillance(CCDRFS)in 2010 were used as baseline data.Eight provinces where CCDRFS were conducted in 2010 were selected,and two surveillance spots(one in urban area and another one in rural area)of each provinces were further selected for the follow-up studies.After excluding diagnosed diabetes patients according to baseline data,a total of 8625 of subjects were recruited as participants.In the follow up carried out from 2016 to 2017,a total of 5991 people received complete follow up.Cox proportional hazards models were used to analyze the relationship between sedentary time and the incidence of type 2 diabetes,and subgroup analysis was conducted based on variables such as gender,geographic area,and urban area or rural areas.Results A total of 5782 subjects were included in final analysis.During an average 6.4 years of follow up(36927.0 person-years),592 participants developed type 2 diabetes,the incidence rate was 16.0 per 1000 person years.Multivariate Cox regression analysis showed that after adjustment for possible confounders,compared with the 0.0-h/d group,the risk of diabetes incidence increased by 33%(HR=1.33,95%CI:1.05-1.68)for those who had sedentary time for more than 6.0 h every day.The subgroup analysis showed that the significant association was only observed in those who were men,current smokers,central obese,had family history of diabetes,had rural residency,and lived in eastern and central areas of China.Conclusions Longer sedentary time can increase the risk of type 2 diabetes.Lifestyle intervention should be strengthened to reduce sedentary time,especially for people who had sedentary time for more than 6.0 h every day.

关 键 词：静坐时间 糖尿病 2型 前瞻性研究 

分 类 号：R587.1[医药卫生—内分泌]