丹参酮和丹酚酸类化合物的生物合成及其转录调控机制  

Biosynthesis and transcriptional regulation of tanshinones and salvianolic acids

作　　者：詹忠根[1] 李杏 ZHAN Zhong-gen;LI Xing(Biophamaceutical Laboratory,Zhejiang Institute of Economics and Trade,Hangzhou 310018,China)

机构地区：[1]浙江经贸职业技术学院生物制药教研室,浙江杭州310018

出　　处：《药学学报》2020年第9期2110-2121,共12页Acta Pharmaceutica Sinica

摘　　要：丹参酮和丹酚酸类化合物是治疗冠心病、心肌梗死、高血压、高血脂、脑卒中等疾病的重要物质基础。近年来,随着基因组学、转录组学、代谢组学和生物信息学的快速发展,其生物合成途径和转录调控机制研究取得较大进展。文章在总结丹参酮和丹酚酸类化合物生物合成最新研究的基础上,着重综述了转录因子对其生物合成的调控作用,认为进一步厘清丹参酮和丹酚酸类化合物的生物合成途径(尤其是下游合成途径的研究)和不同家族转录因子的相互作用、信号响应和协同调控机制,对于挖掘其合成、转运、调节、修饰相关的新基因及揭示调控网络的分子机制十分必要;同时,根据丹参活性成分生物合成规律,人工设计并构建新的、具有特定生理功能的生物系统,从而大幅度提高合成酶基因的表达及活性物质的产量,是有待进一步深入研究的方向之一。Tanshinones and salvianolic acids are important materials in the treatment of coronary heart disease,myocardial infarction,hypertension,hyperlipidemia,stroke and others illnesses.In recent years,with the development of genomics,transcriptome,metabolomics and bioinformatics,many advances have been made in the biosynthesis and transcriptional regulation of tanshinones and salvianolic acids.This paper summarizes these advances and suggests further study on the downstream synthesis pathways and transcriptional regulatory mechanisms to reveal new molecular mechanism of synthesis,transport,regulation and modification.Additionally,we discuss the design and construction of new biological pathways to increase the expression of biosynthesis genes and the production of secondary components,is a newly developing research field.

关 键 词：丹参酮类化合物 丹酚酸类化合物 生物合成途径 转录因子 

分 类 号：R931[医药卫生—生药学]