Improved Fibroblast Adhesion and Proliferation by Controlling Multi-level Structure of Polycaprolactone Microfiber  

作　　者：JIAO Yongjie LI Chaojing LI Qiwei LIU Laijun WANG Fujun WANG Lu 焦勇杰;李超婧;李奇薇;刘来俊;王富军;王璐(Key Laboratory of Textile Science and Technology, Ministry of Education, Donghua University, Shanghai 201620, China;College of Textiles, Donghua University, Shanghai 201620, China)

机构地区：[1]Key Laboratory of Textile Science and Technology,Ministry of Education,Donghua University,Shanghai 201620,China [2]College of Textiles,Donghua University,Shanghai 201620,China

出　　处：《Journal of Donghua University(English Edition)》2020年第4期280-285,共6页东华大学学报（英文版）

基　　金：Fundamental Research Funds for the Central Universities,China(Nos.2232018G-01 and 2232020G-01);Initial Research Funds for Young Teachers of Donghua University,China。

摘　　要：Improving wound healing efficiency is a key issue for high performance dressings.The surface topology of fibers in wound dressings plays an important role in regulating cell behaviors during the regeneration.Herein,a polycaprolactone(PCL)scaffold with a shish-kebab structure was prepared by electrospinning and solution-induced crystallization.L929 cells were used to investigate the behavior of fibroblasts on the multi-level microfiber.The results showed that the shish-kebab fiber-based scaffold enhanced the cell proliferation when compared with the normal fiber and the fiber with a porous structure.Protein absorption,cell adhesive force,and cell modulus also increased by the shish-kebab fiber.The shish-kebab fiber-based scaffold with improved fibroblast-regulation ability can be applied in rapid wound healing.

关 键 词：cell-regulation multi-level microfiber shish-kebab structure electrospinning surface 

分 类 号：R318.08[医药卫生—生物医学工程] TQ340.64[医药卫生—基础医学]