Polymorphism analysis and supertype definition of swine leukocyte antigen class I molecules in three-way crossbred(Landrace,Duroc,and Yorkshire)pigs:implications for the vaccine development of African swine fever virus  

作　　者：Limin Ba Zhenbao Wang William J Liu Dongxun Wu Wangzhen Xiang Peng Qi Chunna Dong Yanxin Hu Ping Lu Jin Xiao Changyuan Yu 

机构地区：[1]College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China [2]Zhongmu Research Institute,China Animal Husbandry Industry Co.,LTD,Beijing 100095,China [3]China Animal Husbandry Industry Co.,LTD,Beijing 100095,China [4]National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention,Beijing 100052,China [5]Key Laboratory of Zoonosis of Ministry of Agriculture,College of Veterinary Medicine,China Agricultural University,Beijing 100094,China [6]China Animal Health and Epidemiology Center,Qingdao 266032,China

出　　处：《Science China(Life Sciences)》2020年第10期1604-1607,共4页中国科学（生命科学英文版）

基　　金：Financed by the National Key R&D Program of China(2017YFD0502302);National 12th Five-Year Plan Science and Technology Support Project(2015BAD12B01-06).

摘　　要：Dear Editor,Swine major histocompatibility complex(MHC)is a highly polymorphic gene in pigs and is also called swine leukocyte antigen(SLA)(Fan et al.,2018).SLA is divided into three major categories,SLA I(SLA-1,-2,-3),SLA II,and SLA III(Smith et al.,2005).SLA I plays an important role in cellular immunity which can eliminate viruses and other foreign antigens in pigs(Macdonald et al.,2010).SLA-1,SLA-2 and SLA-3 are important SLA I alleles and are highly polymorphic.Polymorphism causes extreme difficulties in screening broadly protective cytotoxic lymphocyte(CTL)epitope antigens.The supertype which is built based on peptide-binding specificity of each SLA I can overcome this difficulty to some extent(Thomsen et al.,2013).

关 键 词：SWINE SWINE protective 

分 类 号：S852.4[农业科学—基础兽医学]