血管壁弹性模量对颈动脉狭窄血流储备分数的影响  

The Effect from Elastic Modulus of Vessels on Fractional Flow Reserve of Carotid Artery Stenosis

作　　者：余龙 徐柯淞 万军[2] 王盛章 卢海燕[3] YU Long;XU Kesong;WAN Jun;WANG Shengzhang;LU Haiyan(institute of Biomechanics,Department of Aeronautics and Astronautics,Fudan University,Shanghai200433,China;Department of Intervention,Shanghai Jing'an District Central Hospital,Shanghai 200040,China;Division of Interventional Ultrasound,VIP Clinic,Dongftang Hospital Affliated to Tongi University,Shanghai 200120,China)

机构地区：[1]复旦大学航空航天系,生物力学研究所,上海200433 [2]上海市静安区中心医院介入科,上海200040 [3]同济大学附属东方医院特诊部,介入超声组,上海200120

出　　处：《医用生物力学》2020年第4期265-270,共6页Journal of Medical Biomechanics

基　　金：复旦大学本科生学术研究资助计划(18406);国家自然科学基金项目(81571128,11872152)。

摘　　要：目的探索将血流储备分数(fractional flow reserve,FFR)引入颈动脉狭窄评估的可行性,并且分析血管壁弹性模量对颈动脉狭窄中血液动力学参数和FFR计算结果的影响。方法利用计算机辅助设计软件建立颈动脉分叉标准模型并获得不同狭窄率的模型。假设血管壁为线弹性材料,血液为不可压缩牛顿流体,在脉动流条件下,利用有限元分析软件进行颈动脉狭窄模型中血液流动的流固耦数值模拟,获得各种血液动力学参数,并计算相应的FFR值。结果当弹性模量固定时,随着狭窄率增加,模型中狭窄部位的FFR逐渐减小,且此时其弹性壁与刚性壁的FFR相对差异随着狭窄率的增加而增加;当狭窄率固定为70%时,随着弹性模量增加,FFR会逐渐减小。结论采用FFR对颈动脉狭窄程度进行功能性评估需要考虑血管壁弹性的影响;狭窄率越大,血管壁弹性模量对FFR的影响越大。Objective To explore the feasibility of applying fractional flow reserve (FFR) into the assessment of carotid stenosis,and analyze the effects from elastic modulus of vessel wall on hemodynamic parameters of carotid artery stenosis model and FFR calculation results. Methods The standard models of carotid bifurcation and stenosis models with different stenosis rates were established by computer-aided design software. Assuming that the vessel wall was linear elastic material and the blood was incompressible Newtonian fluid,the fluidstructure coupling simulation of blood flow in carotid artery stenosis model under the pulsating flow was carried out by finite element analysis,and the relevant hemodynamic parameters were obtained,and the corresponding FFR was calculated. Results When the elastic modulus was fixed,the FFR for narrow part of the model decreased gradually with the increase of the stenosis rate,and the relative difference between the FFR of elastic wall and rigid wall increased with the increase of the stenosis rate;when the stenosis rate was fixed at 70%,the FFR decreased gradually with the increase of elastic modulus. Conclusions The effect of vascular wall elasticity should be considered in the process of functional assessment on carotid stenosis with FFR;the larger stenosis rate will lead to the greater influence from elastic modulus of vessel wall on FFR.

关 键 词：颈动脉狭窄 血流储备分数 流固耦合 数值模拟 

分 类 号：R318.01[医药卫生—生物医学工程]