2型糖尿病患者血清MFG-E8水平与骨密度的关系研究  

Study of the relationship between milk fat globule epidermal growth factor 8 and bone mineral density in diabetic patients

作　　者：罗登[1] 冉文卓[2] 叶迎春[1] 高凌[1] LUO Deng;RAN Wenzhuo;YE Yingchun;GAO Ling(Department of Endocrinology,Eastern Branch of Renmin Hospital,Wuhan University,Wuhan 430000,China;Clinical Laboratory,Wuhan No.1 Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430023,China)

机构地区：[1]武汉大学人民医院(东院)内分泌科,湖北武汉430000 [2]武汉市第一医院中心实验室,湖北武汉430023

出　　处：《中国骨质疏松杂志》2020年第9期1279-1281,1286,共4页Chinese Journal of Osteoporosis

基　　金：湖北省自然科学基金项目(2018CFB230);武汉大学腾飞计划之创新种子基金培育项目(TFZZ2018022)。

摘　　要：目的通过比较2型糖尿病(type 2 diabetes mellitus,T2DM)患者不同骨密度(bone mineral density,BMD)状态下乳脂肪球表皮生长因子8(milk fat globule epidermal growth factor 8,MFG-E8)水平的差异,探讨MFG-E8与T2DM患者BMD的关系。方法收集2017年6月至2019年6月我院住院T2DM患者72例,年龄在40~70岁。采用美国双能X线骨密度检测仪对所有患者及年龄、体质指数相匹配的42例健康对照者进行第1-4腰椎(L1-L4)、股骨颈(FN)及全髋(TH)部位BMD检测,依据WHO诊断标准,划分为骨量正常、骨量减少或骨质疏松(osteoporosis,OP)。酶联免疫吸附试验(enzyme linked immunosorbent assay,ELISA)检测患者和健康者血清MFG-E8水平。结果对于健康者和T2DM患者,男性各部位骨密度值、MFG-E8水平均高于女性,差异具有统计学意义(P<0.05)。②糖尿病患者骨量异常发生率高于健康者,糖尿病患者血清MFG-E8低于健康者(P<0.05)。③MFG-E8与L1-L4和TH骨密度正相关,是影响L1-L4和TH骨密度的主要因素。结论MFG-E8具有保护作用,可作为T2DM患者是否发生骨量异常或是否患骨质疏松风险的判别指征。Objective To determine bone mineral density(BMD)and the level of serum milk fat globule epidermal growth factor 8(MFG-E8)in patients with type 2 diabetes mellitus(T2DM),and to investigate the relationship between them.Methods The data of 7240-70-year-old patients with T2DM and 42 normal controls in the hospital from June 2017 to June 2019 were collected.BMD of the lumbar vertebrae(L1-L4),femoral neck(FN),and total hip(TH)in all patients was measured using dual energy X-ray absorptiometry.The subjects were divided into normal bone mass group,bone mass loss group,and osteoporosis group,according to BMD result.Serum level of MFG-E8 was determined using a commercially available ELISA kit.Results The serum MFG-E8 and BMD of each part in male T2DM patients and controls were higher than those in female patients and controls.The incidence of abnormal bone mass in T2DM was higher than that in controls,and the difference was significant(P<0.05).In patients with T2DM,the serum MFG-E8 level was positively correlated with BMD.It was shown that MFG-E8 was one of the main influential factors of BMD in L1-L4 and TH in patients with T2DM.Conclusion MFG-E8 has a protective effect against bone loss and can be used as an indicator of the occurrence of bone loss or osteoporosis in patients with T2DM.

关 键 词：2型糖尿病 骨密度 乳脂肪球表皮生长因子 

分 类 号：R5[医药卫生—内科学]