强直性脊柱炎引起骨代谢紊乱的分子学机制  

Molecular mechanism of bone metabolism disorder by ankylosing spondylitis

作　　者：宋永嘉 王凯 宋志靖[2] 宋敏[2] SONG Yongjia;WANG Kai;SONG Zhijing;SONG Min(School of Rehabilitation Medcine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Gansu University of Traditional Chinese Medicine,Lanzhou 730000,China)

机构地区：[1]上海中医药大学康复医学院,上海201203 [2]甘肃中医药大学,甘肃兰州730000

出　　处：《中国骨质疏松杂志》2020年第9期1382-1385,1390,共5页Chinese Journal of Osteoporosis

基　　金：甘肃省自然科学基金计划(1506RJZA048);甘肃省中医药防治慢性疾病重点实验室开放基金项目(GSMBKY2015-07)。

摘　　要：强直性脊柱炎属于风湿免疫科的常见疾患,以累及骶髂关节和中轴骨的自发性炎症为病变特征,除脊柱关节的进行性退化、功能遭受破坏外,全身性骨代谢紊乱贯穿疾病的始末,后期极易导致脆性骨折的发生,严重影响患者身心健康和生活质量。骨质疏松作为强直性脊柱炎最常见的并发症,其本质还是强直性脊柱炎引起的机体内环境紊乱,破骨细胞与成骨细胞之间脱耦联,骨吸收作用强于骨形成,进一步造成骨代谢失衡、骨量丢失。本文在分子生物学层面围绕强直性脊柱炎造成骨代谢紊乱的具体机制展开综述,阐明二者之间的因果关系,为强直性脊柱炎诊疗过程中积极配合抗骨质疏松治疗提供科学依据,以期更好地指导临床。Ankylosing spondylitis is a common disease in the rheumatology and immunology department.It is characterized by spontaneous inflammation involving the ankle joint and the central axis.In addition to the progressive degeneration of the spinal joint and the destruction of function,systemic bone metabolism disorders are throughout the disease.At the end,it is very easy to cause the occurrence of brittle fractures,that seriously affects the physical and mental health and quality of life of the patient.Osteoporosis is the most common complication of mandatory spondylitis.Its essence is the internal environment disorder caused by ankylosing spondylitis,the decoupling between osteoclasts and osteoblasts,and bone resorption over bone formation,leading to imbalance of bone metabolism and loss of bone mass.In this paper,the specific mechanism of bone metabolism disorder caused by ankylosing spondylitis is reviewed at the molecular biology level,and the causal relationship between them is clarified.It provides a scientific basis for active anti-osteoporosis treatment in the diagnosis and treatment of ankylosing spondylitis.

关 键 词：强直性脊柱炎 骨代谢紊乱 分子学机制 综述 

分 类 号：R274[医药卫生—中医骨伤科学]