In vitro Fertilization with Single-nucleotide Polymorphism Microarray-based Preimplantation Genetic Testing for Aneuploidy Significantly Improves Clinical Outcomes in Infertile Women with Recurrent Pregnancy Loss:A Randomized Controlled Trial  

作　　者：Yi-Lun Sui Cai-Xia Lei Jiang-Feng Ye Jing Fu Shuo Zhang Lu Li Xian-Dong Peng Yue-Ping Zhang Guo-Wu Chen Xiao-Xi Sun 

机构地区：[1]Shanghai Ji Ai Genetics and IVF Institute,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China [2]Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200011,China

出　　处：《Reproductive and Developmental Medicine》2020年第1期32-41,共10页生殖与发育医学（英文版）

基　　金：Shanghai Shenkang Hospital Development Center Program(SHDC12017105).

摘　　要：Objective:To evaluate the effect of preimplantation genetic testing for aneuploidy(PGT-A)in infertile patients with recurrent pregnancy loss(RPL).Methods:A prospective randomized clinical trial was performed in a university-affiliated fertility center in Shanghai,China.Patients in the PGT-A group underwent blastocyst biopsy followed by single-nucleotide polymorphism microarray-based PGT-A and single euploid blastocyst transfer,whereas patients in the control group underwent routine in vitro fertilization/ICSI procedures and frozen embryo transfer of 1-2 embryos selected according to morphological standards.Results:Two hundred and seven infertile patients with RPL were included in this study and randomly assigned to either the control or the PGT-A group.Baseline variables and cycle characteristics were comparable between the two groups.The results showed that PGT-A significantly improved the ongoing pregnancy rate(55.34%vs.29.81%)as well as the live birth rate(48.54%vs.27.88%)and significantly reduced the miscarriage rate(0.00%vs.14.42%)on a per-patient analysis.A significant increase in cumulative ongoing pregnancy rates over time was observed in the PGT-A group.Subgroup analysis showed that the significant benefit diminished for patients who attempted≥2 PGT-A cycles.Conclusions:PGT-A significantly improved the ongoing pregnancy and live birth rate,while reduced miscarriage rate in infertile RPL patients.However,the significance diminished in patients attempting≥2 cycles;thus,further studies are warranted to explore the most cost-effective number of attempts in these patients to avoid overuse.

关 键 词：Assisted Reproductive Treatment Clinical Outcomes Preimplantation Genetic Testing for Aneuploidy Recurrent Pregnancy Loss 

分 类 号：R711.6[医药卫生—妇产科学] R321[医药卫生—临床医学]