抗菌药物联合血必净治疗急性胆囊炎、胆管炎疗效的Meta分析  

A Meta-analysis of Antibiotics Combined with Xuebijing in Prevention of Acute Cholecystitis and Acute Biliary Tract Infection

作　　者：刘玉波[1] 刘家宝[1] 孙岩[1] 阎姝[1] LIU Yu-bo;LIU Jia-bao;SUN Yan(Department of Pharmacy,Tianjin Nankai Hospital,Tianjin(300100),China)

机构地区：[1]天津市南开医院药学部,天津300100

出　　处：《中国中西医结合外科杂志》2020年第5期986-990,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:系统评价抗菌药物联合血必净治疗急性胆囊炎、胆管炎的临床疗效。方法:全面检索PubMed、EMbase、Cochrane Library、CNKI、维普和万方数据库中收录的抗菌药物联合血必净治疗急性胆囊炎、胆管炎的随机对照研究(RCT)文献,检索时限为2000年1月—2019年7月。提取相关资料进行质量评价,采用RevMan 5.3软件进行Meta分析。结果:共纳入9篇RCT文献,包括702例患者。与对照组相比,抗菌药物联合血必净治疗能显著提高临床有效率[OR=3.40,95%CI(2.01,5.84),P<0.0001],显著降低血WBC水平[MD=–1.63,95%CI(–2.49,–0.77),P=0.0002]、PCT水平[MD=–0.24,95%CI(–0.29,–0.19),P<0.00001]以及CRP水平[MD=–2.34,95%CI(–3.16,–1.52),P<0.001]。结论:抗菌药物联合血必净治疗急性胆囊炎、急性胆管炎疗效优于单用抗菌药物,上述结论仍需更多高质量的临床研究进一步验证。Objective Evaluation of efficacy and safety of the combination of antibiotics and Xuebijing for prevention of acute cholecystitis and acute biliary tract infection.Methods Randomized controlled trials(RCT)of the combination of antibiotics and Xuebijing for prevention of acute cholecystitis and acute biliary tract infection were searched from the Cochrane library,EMbase,PubMed,CNKI,VIP and Wanfang database from January 2000 to July 2019.According to the inclusion and exclusion criteria,the data was extracted and processed by Revman5.3.Results Nine randomized controlled trials involving 702 patients were enrolled.The results of Meta-analysis showed that the clinical effect of combined group was significantly better than control group[OR=3.40,95%CI(2.01,5.84),P<0.00001].Xuebijing combined with antibiotics significantly reduced the WBC level[MD=–1.63,95%CI(–2.49,–0.77),P=0.0002],PCT level[MD=–0.24,95%CI(–0.29,–0.19),P<0.00001],CRP level[MD=–2.34,95%CI(–3.16,–1.52),P<0.00001].Conclusion Based on the current clinical evidence,the combination of antibiotics and Xuebijing had better effects on acute cholecystitis and acute biliary tract infection.These findings were required more high-quality and large multicenter randomized controlled trials to verify.

关 键 词：血必净 抗菌药物 急性胆囊炎 急性胆管炎 META分析 

分 类 号：R657.41[医药卫生—外科学]