薤白通脉汤加减对冠心病不稳定型心绞痛患者中医证候积分及血清VEGF、Hcy水平的干预作用  

Effect of Xiebai Tongmai decoction on TCM syndrome score and serum VEGF and Hcy levels in patients with unstable angina pectoris of coronary heart disease

作　　者：王娜 杨琳 WANG Na;YANG Lin(Department of Cardiology,Xi’an Hospital of Traditional Chinese Medicine,Xi’an 710021)

机构地区：[1]西安市中医医院心血管内科,西安710021 [2]陕西省杨凌示范区医院,杨凌712100

出　　处：《陕西中医》2020年第10期1388-1391,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(81673115)。

摘　　要：目的:探讨薤白通脉汤加减对冠心病不稳定型心绞痛(UAP)患者中医证候积分及血清血管内皮生长因子(VEGF)、同型半胱氨酸(Hcy)水平的干预作用。方法:选取122例UAP患者进行前瞻性研究,简单随机化分组,各61例。对照组予以常规治疗,于此基础上,观察组予以薤白通脉汤加减治疗,比较两组治疗前、治疗后中医证候积分、中医证候疗效、心电图疗效、内皮功能指标[血清一氧化氮(NO)、内皮素(ET)]水平、血清VEGF、Hcy水平。结果:观察组治疗后中医证候积分较对照组低(P<0.05);观察组中医证候疗效(93.44%)优于对照组(80.33%,P<0.05);观察组心电图疗效(91.80%)优于对照组(77.05%,P<0.05);观察组治疗后血清NO水平较对照组高,ET水平较对照组低(P<0.05);观察组治疗后血清VEGF水平较对照组高,Hcy水平较对照组低(P<0.05);两组不良反应发生率(9.84%与6.56%)相比,差异无统计学意义(P>0.05)。结论:薤白通脉汤加减治疗冠心病不稳定型心绞痛,可缓解患者心绞痛、心肌缺血等临床症状,改善患者动脉粥样硬化情况与血管内皮功能,疗效显著。Objective:To investigate the intervention effect of Xiebai Tongmai decoction on TCM syndrome scores and serum vascular endothelial growth factor(VEGF)and homocysteine(Hcy)levels in patients with unstable angina pectoris(UAP).Methods:A total of 122 patients with UAP were enrolled in the study.A randomized randomized group of 61 patients was included.The control group received routine treatment.On the basis of this,the observation group was treated with Xiebai Tongmai decoction.The TCM syndrome scores before and after the treatment,the efficacy of TCM syndromes,the electrocardiogram efficacy,and the endothelial function index(serum oxidation)were compared.Nitrogen(NO),endothelin(ET)levels,serum VEGF,Hcy levels.Results:The scores of TCM syndromes in the observation group were lower than those in the control group(P<0.05).The efficacy of TCM syndromes in the observation group(93.44%)was better than that in the control group(80.33%),(P<0.05).The electrocardiogram effect of the observation group was 91.80%,superior to the control group(77.05%P<0.05);the serum NO level in the observation group was higher than that in the control group,and the ET level was lower than that in the control group(P<0.05).The serum VEGF level in the observation group was higher than that in the control group.High,Hcy levels were lower than those in the control group(P<0.05);there was no significant difference between the two groups(9.84%vs 6.56%)(P>0.05).Conclusion:Xiebai Tongmai decoction can reduce the unstable angina pectoris of coronary heart disease,relieve the clinical symptoms such as angina pectoris and myocardial ischemia,improve the atherosclerosis and vascular endothelial function of patients.

关 键 词：薤白通脉汤加减 不稳定型心绞痛 中医证候积分 血管内皮生长因子 同型半胱氨酸 内皮素 

分 类 号：R541.4[医药卫生—心血管疾病]