阿尔茨海默病患者脑动脉及颈动脉硬化与精神行为症状的相关性研究  

Relationships between arteriosclerosis and Hcy level and mental behavior symptoms in Alzheimer’s disease

作　　者：刘锋[1] 师秀雪[1] LIU Feng;SHI Xiuxue(The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《中国实用神经疾病杂志》2020年第20期1797-1801,共5页Chinese Journal of Practical Nervous Diseases

基　　金：河南省科技厅社会发展攻关项目(编号:172102310048)。

摘　　要：目的探讨阿尔茨海默病(AD)患者精神行为症状与动脉粥样硬化的关系。方法选取2019-06—2020-03郑州大学第一附属医院收治的AD患者51例,根据颈部血管超声检查结果分为无IMT增厚或斑块组、IMT增厚或斑块组;根据经颅多普勒超声检查结果将IMT增厚或斑块组进一步分为脑动脉硬化组、无脑动脉硬化组,测定患者血浆同型半胱氨酸(Hcy)水平、简易精神状态量表评分,并进行对比分析。结果IMT增厚或斑块组血浆Hcy水平显著高于无IMT增厚或斑块组(P<0.05);简易精神状况评分比较,IMT增厚或斑块组显著低于无IMT增厚或斑块组(P<0.001)。IMT增厚或斑块组中脑动脉硬化组血浆Hcy水平显著高于无脑动脉硬化组(P<0.001),简易精神状况评分显著低于无脑动脉硬化组(P<0.001)。结论AD患者动脉粥样硬化程度越重,Hcy水平可能越高,且其精神行为症状可能越重。Objective To investigate the relationship between mental behavior symptoms and atherosclerosis in Alzheimer’s disease(AD)patients.Methods 51 consecutives patients with"possible Alzheimer’s disease"admitted in the First Affiliated Hospital of Zhengzhou University from June 2019 to March 2020 were selected and divided into no IMT thickening or plaque group,IMT thickening or plaque group.according to the results of cervical vascular ultrasound examination.According to the results of transcranial Doppler ultrasound,the IMT thickening or plaque group was further divided into cerebral arteriosclerosis group and no cerebral arteriosclerosis group.Then measured the plasma homocysteine(Hcy)level,and the score of the mini mental state scale.Results The plasma Hcy levels in the IMT thickening or plaque group were significantly higher than those in the no IMT thickening or plaque group(P<0.05).Mini mental status score scale comparison showed that existing IMT thickening or plaque group was significantly lower than that in the no IMT thickening or plaque group(P<0.001).The plasma Hcy level in cerebral arteriosclerosis group was significantly higher than that in the no cerebral arteriosclerosis group(P<0.001),and the mini mental status score scale was significantly lower than that in the no cerebral arteriosclerosis group(P<0.001).Conclusion The more severe the degree of atherosclerosis,the higher the Hcy level of AD patients and the more severe the mental and behavioral symptoms perhaps.

关 键 词：阿尔茨海默病 颈动脉粥样硬化 精神行为 同型半胱氨酸 颈动脉斑块 颅多普勒超声 脑动脉硬化 

分 类 号：R445.1[医药卫生—影像医学与核医学]