上海市嘉定区白喉类毒素抗体水平监测  

Antibody levels against diphtheria monitored in Jiading District,Shanghai

作　　者：张倩[1] 钟培松[1] 许言午 费洁[1] 李智[2] 赵根明[3] ZHANG Qian;ZHONG Pei-song;XU Yan-wu;FEI Jie;LI Zhi;ZHAO Gen-ming(Center for Disease Control and Prevention of Jiading District,Shanghai 201800,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;School of Public Health,Fudan University,Shanghai 200032,China)

机构地区：[1]上海市嘉定区疾病预防控制中心,上海201800 [2]上海市疾病预防控制中心,上海200336 [3]复旦大学公共卫生学院,上海200032

出　　处：《上海预防医学》2020年第8期618-621,630,共5页Shanghai Journal of Preventive Medicine

摘　　要：【目的】对上海市嘉定区健康人群白喉抗体水平监测分析,评价白喉类毒素接种策略效果。【方法】2010—2013年在该区采集健康人群血清标本,利用酶联免疫吸附试验(ELISA)检测白喉抗体,比较不同人群白喉抗体几何平均滴度(GMT)。【结果】共调查1029人,白喉IgG抗体GMT为0.325 IU/mL。白喉IgG抗体滴度达到部分保护水平(≥0.01 IU/mL)者1003人,阳性率为97.47%;达到安全保护水平(≥0.1 IU/mL)占70.36%;达到长期保护水平(≥1.0 IU/mL)占35.57%。上海市户籍和外地户籍之间白喉抗体的阳性率和抗体水平差异有统计学意义(χ^2=4.708,P<0.05;t=2.787,P<0.05)。不同年龄组之间白喉抗体阳性率的差异有统计学意义(χ^2=30.262,P<0.001)。各年龄组GMT在0.029 IU/mL(30~岁)~1.526 IU/mL(5~岁)之间,不同年龄组之间的白喉抗体GMT差异有统计学意义(F=99.500,P<0.001)。【结论】上海市嘉定区白喉抗体水平调查结果可真实反映该区白喉常规免疫的接种效果,初中三年级白破(DT)疫苗接种效果显著,可考虑青少年或成人适时接种1剂次含白喉类毒素成分的疫苗以维持免疫水平。[Objective]To investigate the antibody levels against diphtheria among healthy population in Jiading District of Shanghai,and to make evaluation of the effect of diphtheria toxoid vaccination strategy.[Methods]Serum samples were collected from healthy population in Jiading District of Shanghai in 2010-2013.Antibody against diphtheria was tested by the enzyme-linked immunosorbent assay(ELISA).Geometric mean titer(GMT)of diphtheria antibody was compared between different population characteristics.[Results]A total of 1029 serum samples were collected from the healthy population.With 1003 of 1029 diphtheria antibody titer of IgG(over 0.01 IU/mL),the positive rate was 97.47%,reaching the level of security protection(over 0.1 IU/mL)that accounted for 70.36%,and achieving the long-term protection level(over 1 IU/mL)that accounted for 35.57%;IgG GMT 0.325 IU/mL.There was significant difference in the positive rates and antibody levels between city residents and floating population in the field of diphtheria antibodies(χ2=4.708,P<0.05;t=2.787,P<0.05).There were statistically significant differences between different age groups in diphtheria antibody positive rates(χ2=30.262,P<0.001)and statistically significant differences in GMT diphtheria antibody levels between different age groups(F=99.500,P<0.001),GMT ranged in 0.029 IU/mL(30 years age group)~1.526 IU/mL(5 years age group).[Conclusion]The investigation of diphtheria antibody levels in Shanghai Jiading District truly reflects the effect of routine diphtheria immunization in Jiading District.DT(diphtheria&tetanus)vaccination for third grade junior is effective.We suggest a booster dose of diphtheria-containing vaccine for adolescents or adults so as to maintain immune levels.

关 键 词：白喉 抗体水平 酶联免疫吸附试验 

分 类 号：R186[医药卫生—流行病学]