2015—2016年上海市脊髓灰质炎疫苗免疫策略调整前后婴儿抗体水平变化  

Polio antibody levels in infants during 2015-2016 in Shanghai before and after polio vaccination strategy adjustment

作　　者：刘敏勇[1] 黄卓英[1] 陆箐 杨建萍[1] 杨玉颖[1] LIU Min-yong;HUANG Zhuo-ying;LU Jing;YANG Jian-ping;YANG Yu-ying(Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China)

机构地区：[1]上海市疾病预防控制中心,上海200336

出　　处：《上海预防医学》2020年第8期627-630,共4页Shanghai Journal of Preventive Medicine

基　　金：上海市卫生和计划委员会项目(15GWZK0101,GWIV-1)。

摘　　要：【目的】了解2016年上海市实施新的脊髓灰质炎疫苗免疫策略前后婴儿脊髓灰质炎抗体水平的变化情况,为免疫策略的优化提供参考。【方法】应用微量细胞中和实验检测上海市新的脊髓灰质炎疫苗免疫策略实施前后婴儿的抗体水平,并比较抗体水平的变化。【结果】新的脊髓灰质炎疫苗免疫策略实施前后分别检测67名和41名完成基础免疫的健康婴儿血清,其抗体阳性率Ⅰ型、Ⅲ型均达100%。几何平均滴度(GMT)在实施前后分别为Ⅰ型1∶1047.46和1∶254.70,Ⅲ型1∶513.52和1∶185.49。【结论】上海市实施新脊髓灰质炎疫苗免疫策略后婴儿脊灰抗体水平均维持在较高水平。[Objective]To investigate the neutralized antibody level of poliomyelitis among healthy children before and after implementation of the new immunization strategy in Shanghai.[Methods]The poliomyelitis levels of healthy children were detected by neutralization test of the micro cells.[Results]The neutralizing antibody positive rates were 100%for polioⅠand polioⅢbefore and after implementation of the new immunization strategy.GMTs(geometric mean titers)for polioⅠwere 1∶1047.46 before it,and 1∶254.70 after it;those for polioⅢwere 1∶513.52 before it and 1∶185.49 after it.[Conclusion]The neutralized antibody levels of the poliomyelitis among healthy infants maintain a high level before and after implementing the new immunization strategy in Shanghai.

关 键 词：脊髓灰质炎 免疫 疫苗 抗体 

分 类 号：R512.4[医药卫生—内科学]