基于制剂新技术提高氟苯尼考溶解性的研究进展  

Progress on Improving Solubility of Florfenicol Based on New Preparation Technology

作　　者：王志霞 黎欣 武梦茹 谢书宇 陈冬梅[1,2] 陶燕飞[1,2] 黄玲利[1,2] 袁宗辉[1,2] WANG Zhi-xia;LI Xin;WU Meng-ru;XIE Shu-yu;CHEN Dong-mei;TAO Yan-fei;HUANG ling-li;YUAN Zong-hui(College of Veterinary Medicine,Huazhong Agricultural University,Wuhan,Hubei,430070,China;National Reference Laboratory of Veterinary Drug Residues(HZAU),MOA Key Laboratory for the Detection of Veterinary Drug Residues in Foods,Huazhong Agricultural University,Wuhan,Hubei,430070,China)

机构地区：[1]华中农业大学动物医学院,湖北武汉430070 [2]华中农业大学国家兽药残留基准实验室、农业部食品兽药残留检测重点实验室,湖北武汉430070

出　　处：《动物医学进展》2020年第10期91-95,共5页Progress In Veterinary Medicine

基　　金：国家重点研发计划(2017YFD0501402)。

摘　　要：氟苯尼考作为酰胺醇类抗生素,因其广谱高效、吸收快、分布广、半衰期长、无残留或残留低等特点,被列为动物专用抗生素,主要用于治疗禽畜细菌感染性疾病。氟苯尼考的相关制剂已在亚洲、欧洲和美洲的多个国家上市,我国于1999年正式批准氟苯尼考为国家二类新兽药。氟苯尼考在兽药领域发挥着重要的作用,但因为其水溶性差,使得药效发挥受到限制,近年来就如何提高氟苯尼考的溶解性进行了大量的研究。在此基础上,综述了以制剂新技术为手段,改善氟苯尼考溶解度和生物利用度的最新研究进展,从而促进该药的临床应用效果与适用范围。Florfenicol,as an amide alcohol antibiotic,is listed as a special antibiotic for animals due to its broad spectrum,high efficiency,fast absorption,wide distribution,long half-life,no residue or low residue,and is mainly used for treating livestock bacterial infectious diseases.Related preparations of florfenicol have been listed in many countries of Asia,Europe and America.In 1999,China officially approved florfenicol as a national class II new veterinary drug.Florfenicol plays an extremely important role in the field of veterinary drugs,but its poor water solubility limits its efficacy.In recent years,a large number of studies have been conducted on how to improve the solubility of florfenicol.On this basis,the latest research progress in improving the solubility and bioavailability of florfenicol by means of new preparation technologies was reviewed,to promote the clinical application effect and application scope of the drug.

关 键 词：氟苯尼考 制剂新技术 溶解度 生物利用度 

分 类 号：S859.53[农业科学—临床兽医学] S859.796[农业科学—兽医学]