刘丽芳治疗浆细胞性乳腺炎用药规律分析  

Analysis on the Law of Traditional Chinese Medicine Used by LIU Li-fang in Treating Plasma Cell Mastitis

作　　者：周亮[1] 王月[1] 李松莲[2] 罗君 ZHOU Liang;WANG Yue;LI Song-lian;LUO Jun(The First Affiliated Hospital of Hunan University of Chinese Medicine,Changsha Hunan 410007,China;Hunan University of Chinese Medicine,Changsha Hunan 410208,China)

机构地区：[1]湖南中医药大学第一附属医院,湖南长沙410007 [2]湖南中医药大学,湖南长沙410208

出　　处：《中医药导报》2020年第13期102-106,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：湖南省中医药管理局课题(201829),项目名称:基于数据挖掘的浆细胞性乳腺炎中医临床路径的设计与研究。

摘　　要：目的:分析浆细胞性乳腺炎中医用药规律,为该病临床治疗提供参考。方法:选取2013年1月至2018年1月我院乳腺科刘丽芳门诊6个月内痊愈的浆细胞性乳腺炎患者处方,对肿块期、脓肿期、瘘管期中药处方进行药物频数及功效分类频数统计,并对处方用药进行关联规则挖掘及处方药味网络分析。结果:清热解毒类药物用量较多出现在脓肿期,行气活血类药物用量较多出现在肿块期,健脾益气类药物用量较多出现在脓肿期和溃脓期,温阳类药物用量较多出现在肿块期。肿块期置信度最高的关联药物是:醋莪术,昆布→海藻;网络核心药物组成:醋紫胡、蒲公英、金银花、海藻、昆布、醋三棱、醋莪术、醋鳖甲。脓肿期置信度最高的关联药物是:蒲公英、茯苓、黄芪、金银花→白术;网络核心药物组成:茯苓、黄芪、当归、白芷、醋鳖甲、白术、蒲公英、皂角刺、川芎、陈皮、金银花。瘘管期置信度最高的关联药物是:川芎,茯苓,金银花,当归→白术;网络核心药物组成:茯苓、皂角刺、白芷、蒲公英、白术、当归、金银花、川芎。结论:"清、散"之法贯穿整个治疗过程,肿块期少佐温阳类药物,脓肿期结合益气健脾之法以托毒透脓,瘘管期结合益气健脾之法以托里散结。Objective: To analyze the law of traditional Chinese medicine used by LIU Li-fang in the treatment of plasma cell mastitis. Methods: From January 2013 to January 2018, the prescriptions of plasma cell mastitis patients cured in the breast clinic of our hospital within 6 months were selected, and the drug frequency and efficacy classification frequency of traditional Chinese medicine prescriptions in lump stage, abscess stage and fistula stage were statistically analyzed, and the association rules mining and prescription drug taste network analysis were carried out for prescription drugs. Results: The dosage of heat clearing and detoxifying drugs was more in the abscess stage, Qi activating and blood activating drugs were more in the mass stage, spleen strengthening and Qi benefiting drugs were more in the abscess stage and purulent stage, and Yang warming drugs were more in the mass stage. The related drugs with the highest confidence in the mass stage are: Ezhu(curcumae rhizoma), Kunbu(laminariae thallus)→Haizao(sargassum), the network core drug composition: Cuchaihu(bupleuri radix), Pugongying(taraxaci herba), Jinyinhua(lonicerae japonicae flos), Haizao(sargassum), Kunbu(laminariae thallus), Sanleng(sparganii rhizoma), Ezhu(curcumae rhizoma) and Cubiejia(trionycis carapax). The related drugs with the highest confidence in the abscess stage are: Pugongying(taraxaci herba), Fuling(poria),Huangqi(astragali radix), Jinyinhua(lonicerae japonicae flos) →Baizhu(atractylodis macrocephalae rhizoma), the network core drug composition: Fuling(poria), Huangqi(astragali radix), Danggui(angelicae sinensis radix),Baizhi(angelicae dahuricae radux), Cubiejia(trionycis carapax), Baizhu(atractylodis macrocephalae rhizoma), Pugongying(taraxaci herba), Zaojiaoci(gleditsiae spina), Chuanxiong(chuanxiong rhizoma), Chenpi(citri reticulatae pericarpium) and Jinyinhua(lonicerae japonicae flos). The related drugs with the highest confidence in fistula period are Chuanxiong(chuanxiong rhizoma), Fuling(poria), Jinyinhua(lonicerae japon

关 键 词：浆细胞性乳腺炎 中医辨证 分期论治 刘丽芳 用药规律 数据挖掘 

分 类 号：R269[医药卫生—中西医结合]