176例天疱疮住院患者皮损分泌物培养及药敏试验研究  

Microbiological culture of skin lesion exudates and drug sensitivity test in 176 inpatients with pemphigus

作　　者：李秀秀 吴楠 王再兴[1] 李卉[1] 刘盛秀[1] 王红艳[1] 高敏[1] 王培光[1] Li Xiuxiu;Wu Nan;Wang Zaixing;Li Hui;Liu Shengxiu;Wang Hongyan;Gao Min;Wang Peiguang(Department of Dermatology and Venereology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学第一附属医院皮肤性病科,合肥230022

出　　处：《中华皮肤科杂志》2020年第10期791-794,共4页Chinese Journal of Dermatology

摘　　要：目的分析天疱疮患者皮损分泌物培养及药敏试验结果,优化天疱疮的处理方案。方法回顾性分析2008年1月至2018年12月于安徽医科大学第一附属医院皮肤性病科住院的天疱疮患者皮损分泌物培养及药敏试验结果。结果入选患者176例,156例(88.64%)皮损分泌物培养出细菌和/或真菌,包括25种细菌和10种真菌,其中104例(66.67%)培养出1种病原体,52例(33.33%)培养出2种及以上病原体。134例(76.14%)检出革兰氏阳性球菌,其中金黄色葡萄球菌80例、溶血葡萄球菌21例、表皮葡萄球菌16例;66例(37.50%)检出革兰氏阴性杆菌;24例(13.64%)检出真菌。95例复发患者中89例(93.68%)分泌物培养阳性,81例初发患者中67例(82.72%)分泌物培养阳性,两组阳性率比较,χ2=5.22,P<0.05。金黄色葡萄球菌阳性患者药敏试验结果显示,97.26%对万古霉素敏感,97.18%对利奈唑胺敏感,87.14%对利福平敏感。结论天疱疮患者并发皮肤感染常见,以革兰氏阳性球菌感染为主,其中金黄色葡萄球菌对万古霉素、利奈唑胺、利福平的敏感性高。Objective To analyze results of microbiological culture of lesion exudates and drug sensitivity test in patients with pemphigus,and to optimize the management protocol of pemphigus.Methods Inpatients with pemphigus were collected from Department of Dermatology and Venereology,the First Affiliated Hospital of Anhui Medical University from January to December in 2008,and the results of microbiological culture of skin lesion exudates and drug sensitivity test were retrospectively analyzed.Results A total of 176 patients were collected,and skin lesion exudate culture yielded 25 kinds of bacteria and 11 kinds of fungi in 156(88.64%)patients.Of the 156 patients,1 kind of pathogen was yielded in 104(66.67%),and 2 or more kinds of pathogens were yielded in 52(33.33%).Gram-positive cocci were detected in 134(76.14%)cases,including Staphylococcus aureus in 80,Staphylococcus hemolyticus in 21,and Staphylococcus epidermidis in 16;Gram-negative bacilli were detected in 66(37.50%)cases;fungi were detected in 24(13.64%)cases.In addition,89(93.68%)of 95 relapsed patients showed positive culture results,67(82.72%)of 81 patients with newly developed pemphigus had positive culture results,and the positive rate significantly differed between the two groups(χ2=5.22,P<0.05).Drug sensitivity test for Staphylococcus aureus isolates showed that 71(97.26%)of 73 were sensitive to vancomycin,69(97.18%)of 71 to linezolid,and 61(87.14%)of 70 to rifampin.Conclusion Cutaneous infection,especially Gram-positive cocci infection,is very common in patients with pemphigus,and Staphylococcus aureus clinical isolates were highly sensitive to vancomycin,linezolid and rifampicin.

关 键 词：天疱疮 感染 微生物敏感性试验 金黄色葡萄球菌 万古霉素 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]