应用持续葡萄糖监测与气血流注规律分析2型糖尿病患者黎明现象的特点  

A continuous glucose monitoring as well as qi and blood flow rule based analysis on the characteristics of dawn phenomenon of type 2 diabetes

作　　者：孙鼎[1] 田雨[1] 方泓[1] 陆蔚[2] 李成 周健[2] Sun Ding;Tian Yu;Fang Hong;Lu Wei;Li Cheng;Zhou Jian(Medical Department,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Endocrinology,the Sixth People's Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200233,China)

机构地区：[1]上海中医药大学附属龙华医院内科,上海200032 [2]上海交通大学附属第六人民医院内分泌代谢科,上海200233

出　　处：《中国医学前沿杂志（电子版）》2020年第10期62-66,共5页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：国家自然科学基金(81603715)。

摘　　要：目的应用持续葡萄糖监测(continuous glucose monitoring,CGM)系统所采集的夜间21点至次日清晨7点的连续每隔2 h血糖净作用(continuous overlapping net glycemic action 2,CONGA2)与气血流注规律分析2型糖尿病(type 2 diabetes mellitus,T2DM)患者黎明现象的特点。方法选取2007年10月至2008年2月上海交通大学附属第六人民医院门诊招募的正常受试者48例(N组)与新诊断T2DM患者39例,后者进一步分为新诊断T2DM无黎明现象组(NDP组,8例)和新诊断T2DM有黎明现象组(DP组,31例),分时辰段计算第1个24 h中的辰时至第2个24 h中的卯时的CONGA2。结果N组受试者三焦CONGA2均显著高于胆CONGA2、肝CONGA2、肺CONGA2和大肠CONGA2(均P<0.05),胆CONGA2均显著高于肺CONGA2与大肠CONGA2(均P<0.05);DP组受试者三焦CONGA2均显著高于胆CONGA2、肝CONGA2、肺CONGA2和大肠CONGA2(均P<0.05);NDP组受试者三焦CONGA2、胆CONGA2均显著高于肺CONGA2(均P<0.05)。DP组受试者三焦CONGA2、胆CONGA2、肝CONGA2、肺CONGA2和大肠CONGA2均显著高于N组(均P<0.05);三焦CONGA2、胆CONGA2、肝CONGA2和肺CONGA2均显著高于NDP组(均P<0.05)。三焦CONGA2、胆CONGA2、肝CONGA2和肺CONGA2对黎明现象的诊断有意义,且肺CONGA2的诊断效能最大。结论黎明现象的发生与气血流注相关,与正常人相比,新诊断T2DM患者的气血主要影响了胆、肺和大肠的气血流注。Objective To analyze the characteristics of dawn phenomenon(DP)of patients with type 2 diabetes mellitus(T2DM)according to the flow rule of Qi and Blood as well as continuous overlapping net glycemic action 2(CONGA2)collected by a continuous glucose monitoring(CGM)system from 9pm to 7am.Method A total of 48 normal people(group N)and 39 newly diagnosed T2DM patients,who were recruited in the outpatient department of the Sixth People's Hospital Affiliated to Shanghai Jiaotong University from October 2007 to February 2008,were included.The latter was further divided into the newly diagnosed T2DM with no dawn phenomenon group(group NDP,8 cases)and the newly diagnosed T2DM with dawn phenomenon group(group DP,31 cases).CONGA2s for each 2-hour were calculated from 7 to 9 am in the first 24 hours to 5 to 7 am in the second 24 hours.Result In group N,triple energy CONGA2 was significantly higher than gallbladder CONGA2,liver CONGA2,lung CONGA2 and large intestine CONGA2(all P<0.05),gallbladder CONGA2 was significantly higher than lung CONGA2 and large intestine CONGA2(all P<0.05).In group DP,triple energy CONGA2 was significantly higher than gallbladder CONGA2,liver CONGA2,lung CONGA2 and large intestine CONGA2(all P<0.05).In group NDP,triple energy CONGA2 and gallbladder CONGA2 were higher than lung CONGA2(all P<0.05).Triple energy CONGA2,gallbladder CONGA2,liver CONGA2,lung CONGA2 and large intestine CONGA2 of group DP were all significantly higher than that of group N(all P<0.05),while triple energy CONGA2,gallbladder CONGA2,liver CONGA2 and lung CONGA2 of group DP were significantly higher than those of group NDP(all P<0.05).Triple energy CONGA2,gallbladder CONGA2,liver CONGA2 and lung CONGA2 were significant for the diagnosis of dawn phenomenon,and the diagnostic efficacy of lung CONGA2 was the largest.Conclusion We have observed that the occurrence of the dawn phenomenon was related to the qi and blood flow of traditional Chinese medicine.Compared with normal people,the Qi and Blood of newly diagnosed T2DM patients

关 键 词：黎明现象 持续葡萄糖监测 子午流注 连续每隔数小时血糖净作用 

分 类 号：R587.1[医药卫生—内分泌]