姜黄素二聚体载药纳米粒的制备与性能研究  

Preparation and properties of curcumin dimer loaded nanoparticles

作　　者：文纳川 刘珍宝 杜沛芳 侯姣姣 刘艳飞[1] WEN Nachuan;LIU Zhenbao;DU Peifang;HOU Jiaojiao;LIU Yanfei(School of Chemistry and Chemical Engineering,Central South University,Changsha 410083,China;Xiangya School of Pharmaceutical Sciences,Central South University,Changsha 410013,China)

机构地区：[1]中南大学化学化工学院,湖南长沙410083 [2]中南大学湘雅药学院,湖南长沙410013

出　　处：《中南大学学报（自然科学版）》2020年第9期2389-2395,共7页Journal of Central South University:Science and Technology

基　　金：湖南省自然科学基金资助项目(2020JJ4680);湖南省研究生自主探索创新项目(CX20190184);湖湘青年英才项目(2018RS3005);中南大学升华育英计划项目(CX20190242)。

摘　　要：为了提高抗肿瘤药物姜黄素载药效率,以姜黄素为单元合成新型姜黄素二聚体(CUR2-TK),并以聚乙二醇−聚乳酸羟基乙酸共聚物(PEG-PLGA)为载体,通过单乳液溶剂挥发法,制备姜黄素二聚体缓释纳米粒,研究不同药物CUR2-TK与聚合物PEG-PLGA的质量比(m(CUR2-TK):m(PEG-PLGA))等对纳米粒性能的影响。研究结果表明:通过姜黄素二聚体构建的载药纳米粒具备极高的载药效率,在m(CUR2-TK):m(PEG-PLGA)为3:1时,载药量和包封率分别达到(61.9±2.9)%和(80.1±3.8)%,且纳米粒形貌规整均一,粒径可控在50~100 nm之间,释药时间达4 d以上。In order to improve the drug loading efficiency of antitumor drug curcumin,a new curcumin dimer(CUR2-TK)was synthesized using curcumin as a unit,and polyethylene glycol-polylactic acid-glycolic acid copolymer(PEG-PLGA)used as a carrier,curcumin dimer loaded sustained-release nanoparticles were prepared by a single emulsion solvent volatilization method,and the effects of different experimental conditions such as the mass ratio of different drugs to polymer(m(CUR2-TK):m(PEG-PLGA))on the performance of nanoparticles were studied.The results show that the drug-loaded nanoparticles constructed by curcumin dimer have extremely high drug-loading efficiency.Under the condition of m(CUR2-TK):m(PEG-PLGA)=3:1,the drug load and entrapment efficiency reaches(61.9±2.9)%and(80.1±3.8)%,respectively,and the nanoparticles are uniform in appearance and the particle size can be controlled between 50 and 100 nm.The drug release of the nanoparticles is up to 4 d.

关 键 词：姜黄素二聚体 聚乙二醇聚乳酸羟基乙酸 纳米粒 药物传递体系 

分 类 号：O633[理学—高分子化学]