Stem cell treatments for oropharyngeal dysphagia:Rationale,benefits,and challenges  

作　　者：Eric K Tran Kevin O Juarez Jennifer L Long 

机构地区：[1]David Geffen School of Medicine,University of California-Los Angeles,Los Angeles,CA 90095,United States [2]Department of Otolaryngology,Yale School of Medicine,New Haven,CT 06511,United States [3]Department of Head and Neck Surgery,David Geffen School of Medicine,University of California-Los Angeles,Los Angeles,CA 90095,United States [4]Greater Los Angeles VA Healthcare System,Los Angeles,CA 90073,United States

出　　处：《World Journal of Stem Cells》2020年第9期1001-1012,共12页世界干细胞杂志（英文版）（电子版）

摘　　要：Dysphagia,defined as difficulty swallowing,is a common symptom negatively impacting millions of adults annually.Estimated prevalence ranges from 14 to 33 percent in those over age 65 to over 70 percent in a nursing home setting.The elderly,those with neurodegenerative diseases,head and neck cancer patients,and those with autoimmune conditions such as Sjögren's syndrome are disproportionately affected.Oropharyngeal dysphagia refers specifically to difficulty in initiating a swallow due to dysfunction at or above the upper esophageal sphincter,and represents a large proportion of dysphagia cases.Current treatments are limited and are often ineffective.Stem cell therapy is a new and novel advancement that may fill a much-needed role in our treatment regimen.Here,we review the current literature regarding stem cell treatments for oropharyngeal dysphagia.Topics discussed include tissue regeneration advancements as a whole and translation of these principles into research surrounding tongue dysfunction,xerostomia,cricopharyngeal dysfunction,and finally an overview of the challenges and future directions for investigation.Although this field of study remains in its early stages,initial promising results show potential for the use of stem cell-based therapies to treat oropharyngeal dysphagia and warrant further research.

关 键 词：DYSPHAGIA XEROSTOMIA Hemiglossectomy Stem cells MYOBLASTS Mesenchymal stem cells 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]