Association of vitamin D and knee osteoarthritis in younger individuals  

作　　者：Sujit Kumar Tripathy Amrit Gantaguru Saurav Narayan Nanda Sandeep Velagada Anand Srinivasan Manaswini Mangaraj 

机构地区：[1]Department of Orthopaedics,All India Institute of Medical Sciences,Bhubaneswar,Bhubaneswar 751019,Odisha,India [2]Department of Pharmacology,AIIMS Bhubaneswar,Bhubaneswar 751019,Odisha,India [3]Department of Biochemistry,AIIMS Bhubaneswar,Bhubaneswar 751019,Odisha,India

出　　处：《World Journal of Orthopedics》2020年第10期418-425,共8页世界骨科杂志（英文版）

摘　　要：BACKGROUND The incidence of primary osteoarthritis knee is gradually increasing among young individuals.The increasing prevalence of obesity,sedentary lifestyle,sporting activity,and vitamin D deficiency(VDD)has been hypothesized for this shifting disease trend.This study was designed to look for the association of serum vitamin D among these young arthritic patients.AIM To look for the association of serum vitamin D in younger knee osteoarthritis(KOA)patients.METHODS In a 2-year observational study,146 non-obese KOA patients of 35-60 years were evaluated clinically(Knee injury and Osteoarthritis Outcome Score,KOOS)and radiologically(Kellegren-Lawrence stage,KL).The serum 25(OH)D level of these patients and 146 normal healthy individuals of same age group were estimated.RESULTS Both the groups were comparable in terms of age and sex.The average serum 25(OH)D level in healthy individuals and KOA patients was 45.83 ng/mL and 34.58 ng/mL,respectively(P<0.001).Inadequate serum 25(OH)D level(<30 ng/mL)was found in 46.57%of KOA patients and 24%of normal healthy participants indicating a significant positive association(odds ratio 2.77,95%CI:1.67-4.54,P<0.001).The 25(OH)D level in KL grade I,II,III and IV was 43.40,30.59,31.56 and 33.93 ng/mL respectively(no difference,P=0.47).Similarly,the KOOS score in sufficient,insufficient and deficient groups were 65.31,60.36 and 65.31,respectively(no difference,P=0.051).CONCLUSION The serum 25(OH)D level is significantly low in younger KOA patients.However,the clinical and radiological severities have no association with serum vitamin D level.

关 键 词：Degenerative disease Early-onset arthritis CHOLECALCIFEROL SUNLIGHT Knee joint ARTHROPLASTY Knee replacement 

分 类 号：R684.3[医药卫生—骨科学]