成都地区11家医院2016—2018年抗菌药物应用分析  

Application analysis of antibiotics in 11 Chengdu hospitals during 2016—2018

作　　者：樊新星[1] 孙山[1] 邹亮[2] 方道硕[1] 杨志勇[1] 陈加容[1] Fan Xin-xing;Sun Shan;Zou Liang;Fang Dao-shuo;Yang Zhi-yong;Chen Jia-rong(Pharmacy Department,Affiliated Hospital of Chengdu University,Chengdu 610081;College of Medical,Chengdu University,Chengdu 610106)

机构地区：[1]成都大学附属医院药剂科,成都610081 [2]成都大学医学院,成都610106

出　　处：《中国抗生素杂志》2020年第7期706-712,共7页Chinese Journal of Antibiotics

摘　　要：目的分析成都地区全身用抗菌药物的临床应用情况,为抗菌药物的合理使用提供参考。方法采用限定日剂量(DDD)方法,对《医院处方分析合作项目》课题中成都地区11家医院2016—2018年抗菌药物的使用金额、用药频度(DDDs)等进行统计分析。结果近3年成都地区抗菌药物使用金额呈逐年上升趋势,头孢哌酮钠/三唑巴坦钠一直居近3年的使用量榜首,伏立康唑次之。喹诺酮类药物中莫西沙星、左氧氟沙星应用广泛,用药频度近3年一直靠前。特殊级抗菌药物替加环素、美罗培南增长明显;住院患者β-内酰胺含酶抑制剂呈上升趋势,头孢哌酮钠/舒巴坦钠增长明显,门诊患者第三代头孢菌素使用金额及用药频度3年持续增长,第二代头孢菌素呈下降趋势。结论成都地区11家医院全身用抗菌药物用药金额呈逐年上升趋势,使用基本合理,但仍需注意药物选择偏好与耐药菌的关系,建议根据药敏结果结合临床选药,经验选药时需关注本地区细菌耐药情况,做好个体化用药,注意选药的安全、有效、经济。Objective To analyze the utilization of systemic antibiotics in Chengdu and provide references for the rational use of antibiotics. Methods Using the defined daily dose(DDD) method, statistical analysis of the amount of antibiotics used and the frequency of drug use(DDDs) in 11 hospitals in Chengdu from 2016 to 2018. The data source was the subject of the Hospital Prescription Analysis Cooperation Project. Results In the past three years, the drug using sum of Chengdu presented raising tendency year by year. In the past three years, cefoperazone tazobactam has been the most widely used drug, followed by voriconazole. The DDDs of moxifloxacin and levofloxacin in quinolone drugs have been ahead for nearly three years. In the special grade antimicrobial drugs, the DDDs of tegacycline and meropenem increased significantly. In hospitalized patients, beta-lactam enzyme inhibitors showed an upward trend and cefoperazone sulbactam increased significantly. The consumption sum and DDDs of the third generation cephalosporins in outpatients increased continuously in the past three years, while the second generation cephalosporins showed a downward trend. Conclusion In the past three years, the use of systemic antibiotics in 11 hospitals in Chengdu has been gradually increasing. The use is basically reasonable, but it is still necessary to pay attention to the relationship between drug selection preferences and drug-resistant bacteria. It is recommended that drug selection should be based on drug susceptibility results in combination with clinical drug selection. When selecting drugs, we should consider the safety, effectiveness, and economy of drugs. We should pay attention to individualized use of antibiotics.

关 键 词：抗菌药物 限定日剂量 使用金额 用药频度 

分 类 号：R978.1[医药卫生—药品]