黄芪多糖在肠道黏膜诱导的内毒素耐受样免疫反应研究进展  

Astragalus Polysaccharides Induces Endotoxin Tolerance Response in Intestinal Mucosa

作　　者：李玉龙[1,2] 杨健涛 杨志强 姚军虎 杨小军[1] LI Yulong;YANG Jiantao;YANG Zhiqiang;YAO Junhu;YANG Xiaojun(College of Animal Science and Technology,Northwest A&F University,Shaanxi Yangling 712100,China;College of Basic Medical Science,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712083,China;Shandong Province feed inspection institute,Shandong Jinan,250000)

机构地区：[1]西北农林科技大学动物科技学院,陕西杨凌712100 [2]陕西中医药大学基础医学院,陕西咸阳712000 [3]山东省饲料检验所,山东济南250000

出　　处：《中国畜牧杂志》2020年第10期17-22,共6页Chinese Journal of Animal Science

基　　金：国家重点研发计划项目(2017YFD0500500);国家自然科学基金(31972529、31272464、31001017)。

摘　　要：黄芪多糖是一种具有高效免疫调控效应的中草药提取物,动物摄入后可诱导肠道黏膜免疫系统TLR4通路内毒素耐受免疫反应,进而影响肠道黏膜免疫功能状态,优化动物肠道黏膜组织形态和健康状态。本文对黄芪多糖的免疫调控机理及其对肠道黏膜免疫系统的影响进行总结,以期为后续研究提供参考。Astragalus Polysaccharides(APS)is a kind of herbal extract which is highly effective in immunomodulation.After ingested,APS could be recognized and bound by Toll like receptor 4(TLR4)located on the membrane of intestinal epithelial cells(IECs),and induce an endotoxin-tolerance like immune response,which will further optimize the morphology of intestinal mucosa.In this review,we summarize and discuss the regulative mechanism of APS on intestinal mucosal immune system,which may provide a useful reference for further research.

关 键 词：黄芪多糖 肠道黏膜免疫 内毒素耐受 

分 类 号：S816.7[农业科学—饲料科学]