新型隐球菌感染病例分布及其耐药性分析  

Distribution of cases of cryptococcus neoformans infection and analysis of its drug resistance

作　　者：董秀涛 程芳 Dong Xiutao;Cheng Fang(Department of Laboratory,Qianfoshan Hospital,Jinan,Shandong 250001,China)

机构地区：[1]千佛山医院检验科,山东济南250001

出　　处：《医药前沿》2020年第18期22-24,共3页Journal of Frontiers of Medicine

摘　　要：目的:了解我院新型隐球菌感染现状并对其耐药性进行分析。方法:分析我院2017年1月-2019年5月期间所有送检的脑脊液培养标本,根据培养结果筛查出住院病人新型隐球菌脑膜炎感染病例19例。并对其临床症状、年龄构成、实验室检查及药物敏感试验进行分析。结果:新型隐球菌脑膜炎其临床特征缺乏特异性,临床误诊率较高;新型隐球菌脑膜炎多继发在免疫缺陷患者中,如长期服用免疫抑制剂、艾滋病患者及长期化疗者,并以慢性、亚急性发病居多;药敏结果显示,针对新型隐球菌脑膜炎患者的治疗,联合用药效果好于单一用药效果。结论:新型隐球菌感染的临床表现因缺乏特异性,误诊率较高,及时有效地诊断、快速准确的病原菌检测与对症治疗是治愈新型隐球菌脑膜炎的关键。Objective To understand the present situation of cryptococcus neoformant infection in our hospital and analyze its drug resistance.Methods From January 2017 to May 2019 makes all specimens of CSF cultures,according to the result of culture screening out of cryptococcus neoformans meningitis cases of infection in hospital patients,a total of 19 cases,and the qualified were retrospectively analyzed,and the clinical symptoms,age composition,laboratory tests and drug sensitive test.Results The clinical characteristics of cryptococcal meningitis were lack of specificity and the misdiagnosis rate was high.Cryptococcal meningitis secondary in immunodeficiency patients,such as long-term use of immunosuppressive drugs,AIDS patients and long-term chemotherapy,and chronic,subacute morbidity in the majority;The drug sensitivity results showed that the combined treatment was better than the single treatment for patients with cryptococcal meningitis.Conclusion Due to the lack of specificity in clinical manifestations of Cryptococcal infection,the misdiagnosis rate is relatively high.Timely and effective diagnosis,rapid and accurate pathogen detection and symptomatic treatment are the keys to cure cryptococcal meningitis.

关 键 词：新型隐球菌 病原菌 实验室检查 临床特征 

分 类 号：R378.1[医药卫生—病原生物学]