高口服生物利用度胰岛素纳米制剂的研究进展  

Insulin nanoparticles with high oral bioavailability:research progress

作　　者：王思琦 张咏馨 赵元骞 梁旭 吴正红[3] 季鹏 WANG Si-qi;ZHANG Yong-xin;ZHAO Yuan-qian;LIANG Xu;WU Zheng-hong;JI Peng(School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,Jiangsu,China;School of Life Science and Technology,China Pharmaceutical University,Nanjing 211198,Jiangsu,China;School of Pharmacy,China Pharmaceutical University,Nanjing 211198,Jiangsu,China;College of Pharmacy and Chemistry and Chemical Engineering,Taizhou University,Taizhou 225300,Jiangsu,China)

机构地区：[1]中国药科大学中药学院,南京211198 [2]中国药科大学生命科学与技术学院,南京211198 [3]中国药科大学药学院,南京211198 [4]泰州学院医药与化学化工学院,泰州225300

出　　处：《第二军医大学学报》2020年第9期1027-1030,共4页Academic Journal of Second Military Medical University

基　　金：江苏省研究生培养创新工程项目(KYCX18_0760).

摘　　要：糖尿病是一种以血糖水平的动态平衡发生改变为特征的慢性代谢性疾病。胰岛素皮下注射是治疗糖尿病的重要方法,但存在疼痛不适和局部感染等不良反应,导致患者依从性低。口服给药途径方便、安全,但现有的口服胰岛素制剂存在胃肠道不稳定、生物利用度差等问题,仍需优化。纳米制剂技术的快速发展为提高口服胰岛素制剂的生物利用度、实现胰岛素的有效口服递送提供了坚实的基础,本文对近年来高口服生物利用度胰岛素纳米制剂的研究进展作一综述。Diabetes is a chronic metabolic disease characterized by changes in the dynamic balance of blood glucose levels.Subcutaneous injection of insulin is a first-line treatment for diabetes.However,patient compliance is poor due to pain,discomfort,and local infection.Oral administration is convenient and safe,but the existing oral insulin preparations still need to be optimized due to gastrointestinal instability and poor bioavailability.The rapid development of nanopreparation technology provides a solid foundation for improving the bioavailability of oral insulin preparations and achieving the effective oral delivery of insulin.This paper reviews the research progress in insulin nanoparticles with high oral bioavailability in recent years.

关 键 词：糖尿病 胰岛素 纳米粒子 药物输送系统 

分 类 号：R587.1[医药卫生—内分泌] R943.4[医药卫生—内科学]