Combined liver and kidney transplantation in children and long-term outcome  

作　　者：Randula Ranawaka Kavinda Dayasiri Manoji Gamage 

机构地区：[1]Department of Paediatrics,Faculty of Medicine,University of Colombo and Lady Ridgeway Hospital for Children,Colombo 0094,Sri Lanka [2]Department of Paediatrics,Base Hospital Mahaoya,Mahaoya 0094,Sri Lanka [3]Department of Clinical Nutrition,Lady Ridgeway Hospital for Children,Colombo 0094,Sri Lanka

出　　处：《World Journal of Transplantation》2020年第10期283-290,共8页世界移植杂志

摘　　要：Combined liver-kidney transplantation(CLKT)is a rarely performed complex surgical procedure in children and involves transplantation of kidney and either whole or part of liver donated by the same individual(usually a cadaver)to the same recipient during a single surgical procedure.Most common indications for CLKT in children are autosomal recessive polycystic kidney disease and primary hyperoxaluria type 1.Atypical haemolytic uremic syndrome,methylmalonic academia,and conditions where liver and renal failure co-exists may be indications for CLKT.CLKT is often preferred over sequential liver-kidney transplantation due to immunoprotective effects of transplanted liver on renal allograft;however,liver survival has no significant impact.Since CLKT is a major surgical procedure which involves multiple and complex anastomosis surgeries,acute complications are not uncommon.Bleeding,thrombosis,haemodynamic instability,infections,acute cellular rejections,renal and liver dysfunction are acute complications.The long-term outlook is promising with over 80%5-year survival rates among those children who survive the initial six-month postoperative period.

关 键 词：Combined liver-kidney transplantation IMMUNOPROTECTION Long-term outcomes Renal allograft survival Acute cellular rejection Autosomal recessive polycystic kidney disease 

分 类 号：R69[医药卫生—泌尿科学]