HBP、PCT在社区获得性肺炎早期辅助诊断及病情评估中的价值比较  

The Comparative Study of Heparin Binding Protein and Procalcitonin in the Early Diagnosis and Condition Evaluation of Community Acquired Pneumonia

作　　者：吴洁[1] 立彦[1] 朱功民 邱樊[1] WU Jie;LI Yan;ZHU Gongmin;QIU Fan(Department of Nuclear Medicine,Nanjing First Hospital,Nanjing Medical University,Nanjing 210006,China)

机构地区：[1]南京医科大学附属南京医院(南京市第一医院)核医学科,江苏南京210006

出　　处：《标记免疫分析与临床》2020年第9期1482-1486,共5页Labeled Immunoassays and Clinical Medicine

基　　金：国自然青年科学基金项目(编号:11805104)。

摘　　要：目的比较肝素结合蛋白(heparin binding protein,HBP)、降钙素原(procalcitonin,PCT)检测在社区获得性肺炎(community acquired pneumonia,CAP)早期辅助诊断及病情评估中的临床价值。方法选取2018年9月至2019年2月南京医科大学附属南京医院收治的131例CAP患者作为研究组,分为普通CAP组85例,重症CAP组46例。同期31名健康体检者作为对照组。测定血浆中HBP及PCT水平,进一步比较各组间HBP、PCT的水平差异,受试者工作特征(ROC)曲线分析HBP、PCT在早期辅助诊断CAP及其病情评估的价值。结果各组间性别、年龄分布差异无统计学意义(P>0.05)。CAP患者HBP为23.71(3.90~252.83)ng/mL明显高于健康对照组(P<0.05),而两组间的PCT差异无统计学意义(P=0.512>0.05)。重症CAP组HBP、PCT分别为79.55(29.62~252.83)ng/mL、0.40(0.08~32.23)ng/mL,均明显高于CAP组(P<0.05)。HBP可有效辅助诊断CAP,AUC为0.858,cut-off值为12.31 ng/mL时,灵敏度为78.60%,特异性为90.30%。辅助病情评估时,HBP、PCT AUC分别为0.893、0.674,灵敏度分别为93.50%、71.70%,特异性分别为74.10%、58.80%。结论在CAP的早期辅助诊断及病情评估中,HBP较PCT有更好的价值。Objective The aim of this study was to compare the clinical values of heparin binding protein(HBP)and procalcitonin(PCT)in the early diagnosis and condition evaluation of community acquired pneumonia(CAP).Methods From September,2018 to February,2019,131 cases of CAP admitted to Nanjing Hospital Affiliated to Nanjing Medical University and 31 cases of health control were included in this study.85 cases were divided into the common cap group and 46 cases in the severe CAP group.The concentrations of HBP and PCT in plasma of these subjects were determined and compared among groups.The ROC curves of different groups were compared and used to analyze the value of HBP and PCT in the early diagnosis and condition evaluation of community acquired pneumonia.Results There was no significant difference in gender and age distribution among groups(P>0.05).The HBP of the CAP group was 23.71(3.9-252.83)ng/mL,which was significantly higher than that of the health control(P<0.05),while there was no significant difference in PCT between the two groups(P=0.512>0.05).HBP and PCT in the severe pneumonia group were 79.55(29.62-252.83)ng/mL and 0.40(0.08-32.23)ng/mL,respectively,which were significantly higher than those in the general community acquired pneumonia group(P<0.05).When used to analyze the condition of CAP patients,the AUC of HBP and PCT were 0.893 and 0.674,respectively.The sensitivities were 93.50%and 71.70%,and the specificities were 74.10%and 58.80%,respectively.Conclusion HBP is more valuable than PCT in the early diagnosis and evaluation of CAP.

关 键 词：社区获得性肺炎 降钙素原 肝素结合蛋白 辅助诊断 病情评估 

分 类 号：R446[医药卫生—诊断学]