不同钙浓度透析液在老年MHD伴动力缺失性肾性骨病患者治疗中的效果差异  

The Effect of Dialysate with Different Calcium Concentrations in the Treatment of Senile MHD Patients with Dynamic Loss of Renal Osteopathy

作　　者：廖琳[1] 路建饶[1] 陈杰[1] 陈晛[1] 胡静[1] 张传富[1] 韩海燕[1] 郭玥 LIAO Lin;LU Jianrao;CHEN Jie;CHEN Xian;HU Jing;ZHANG Chuanfu;HAN Haiyan;GUO Yue(Department of Nephropathy,the Seventh People’s Hospital of Shanghai University of TCM,Shanghai 200173,China)

机构地区：[1]上海中医药大学附属第七人民医院肾病科,上海200137

出　　处：《标记免疫分析与临床》2020年第9期1487-1490,1541,共5页Labeled Immunoassays and Clinical Medicine

基　　金：上海中医药大学附属第七人民医院人才培养计划项目(编号:QMX2019-02);上海市浦东新区卫生健康委员会卫生计生科研项目(编号:PW2019A19)。

摘　　要：目的探讨不同钙浓度的透析液在老年维持性血透(maintenance hemodialysis,MHD)伴动力缺失性肾性骨病(renal osteodystrophy,ROD)患者治疗中的效果差异。方法选取2017年2月至2019年12月本院收治的老年MHD伴动力缺失性ROD患者96例,采用随机数字表法分为A组(含钙1.25 mmol/L的透析液)、B组(含钙1.50 mmol/L的透析液)各48例,两组患者均连续性实施透析治疗12个月。结果治疗后,A组患者的血钙、血磷低于B组(P<0.05),iPTH、骨密度T值高于B组(P<0.05);A组患者的IMT、RI、IVRT测定值均低于B组(P<0.05),E/A高于B组(P<0.05)。结论含钙1.25 mmol/L的透析液在老年MHD伴动力缺失性ROD患者治疗中对于调节患者血钙、血磷代谢、甲状旁腺素、颈动脉硬化、骨代谢等方面具有积极作用。Objective To explore the difference of the effect of dialysate with different calcium concentrations in the treatment of elderly patients with MHD and ROD.Methods A total of 96 elderly patients of MHD with dysfunctional ROD admitted to our hospital from February,2017 to December,2019 were selected and divided into group A(containing 1.25 mmol/L calcium dialysate)and group B(including Calcium 1.50mmol/L dialysate),with 48 cases each.Both groups of patients were continuously on dialysis treatment for 12 months.Results After treatment,the blood calcium and blood phosphorus in group A were lower than those in group B(P<0.05),and the T values of iPTH and BMD were higher than those in group B(P<0.05).After treatment,IMT,RI,IVRT of group A patients were lower than those in group B(P<0.05),while E/A was higher than group B(P<0.05).Conclusion The dialysate containing 1.25 mmol/L calcium has a positive effect on the regulation of blood calcium,blood phosphorus metabolism,parathyroid hormone,carotid atherosclerosis,and bone metabolism,etc.,in the treatment of elderly patients of MHD with dysmotility ROD.

关 键 词：钙 透析液 老年 维持性血透 肾性骨病 

分 类 号：R459.5[医药卫生—治疗学]