重组人干扰素α-1b联合人免疫球蛋白对毛细支气管炎重症患儿炎性因子及氧化应激指标的影响  

Effects of Recombinant Human Interferonα-1b Combined with Human Immunoglobulin on Inflammatory Factors and Oxidative Stress Indexes in Children with Severe Bronchiolitis

作　　者：王岩[1] 黄雅玲[1] 高健[1] WANG Yan;HUANG Yaling;GAO Jian(Department of Pediatrics,Fuxin General Hospital of MiningIndustar Group,Fuxin 123000,China)

机构地区：[1]辽宁省健康产业集团阜新矿总医院(中国医科大学第十临床学院)儿科,辽宁阜新123000

出　　处：《标记免疫分析与临床》2020年第9期1588-1592,共5页Labeled Immunoassays and Clinical Medicine

摘　　要：目的探讨重组人干扰素α-1b联合人免疫球蛋白对毛细支气管炎重症患儿炎性因子及氧化应激指标的影响。方法选择2016年1月至2018年2月于我院接诊的毛细支气管炎重症患儿86例,通过随机数表法分为观察组和对照组,两组各43例,对照组给予重组人干扰素α-1b雾化吸入治疗,观察组在对照组基础上联合人免疫球蛋白进行肌肉注射治疗,两组均连续治疗1周。比较两组患儿症状改善情况、T淋巴细胞亚群、肺功能、炎性因子、氧化应激指标的变化情况,并记录两组不良反应的发生情况。结果观察组喘憋、咳痰、高热、啰音消失时间明显短于对照组(P<0.05);观察组CD3+、CD4+、CD8+均高于对照组,CD4+/CD8+低于对照组(P<0.05);肺功能中,观察组第一秒最大呼气容积(FEV1)、FEV1与用力肺活量比值(FEV1/FVC)、最大呼气流量(PEF)明显高于对照组(P<0.05);观察组炎性因子血清C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)指标水平均低于对照组(P<0.05);观察组丙二醛(MDA)明显低于对照组,观察组超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)明显高于对照组(P<0.05);观察组和对照组的不良反应发生率分别为2.33%和11.63%,差异无统计学意义(P>0.05)。结论重组人干扰素α-1b联合人免疫球蛋白可显著改善毛细支气管炎重症患儿的临床症状和肺功能,有效抑制炎症因子表达和氧化应激指标,值得临床推广。Objective To study effects of recombinant human interferonα-1b combined with human immunoglobulin on inflammatory factors and oxidative stress indexes in children with severe bronchiolitis.Methods From January,2016 to February,2018,86 children with severe bronchiolitis in our hospital were selected for the study.They were divided into the observation group and the control group by the random number table method,with 43 cases in each group.The control group was treated by aerosol inhalation of recombinant human interferonα-1b,while the observation group was treated with intramuscular injection of human immunoglobulin in addition of the control group,and both groups were treated for one week.The improvement of symptoms,T lymphocyte subsets,lung function,inflammatory factors and oxidative stress indexes,and the occurrence of adverse reactions were compared between the two groups.Results The disappearance time of asthmatic suffocation,expectoration,fever and rales in the observation group were significantly shorter than those in the control group(P<0.05).CD3+,CD4+,CD8+in the observation group were higher than those in the control group,while CD4+/CD8+were lower than those in the control group(P<0.05).For pulmonary function indexes,the FEV1,FEV1/FVC and PEF of the observation group were significantly higher than those of the control group(P<0.05).The levels of serum C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those in the control group(P<0.05).MDA in the observation group was significantly lower than that in the control group,while SOD and GSH-PX in the observation group were significantly higher than those in the control group(P<0.05).The incidence of adverse reactions in the observation group and the control group were 2.33%and 11.63%,respectively,with no significant difference(P>0.05).Conclusion Recombinant human interferonα-1b combined with human immunoglobulin can significantly improve the clinical symptoms and lung function of childre

关 键 词：毛细支气管炎重症患儿 重组人干扰素Α-1B 人免疫球蛋白 

分 类 号：R725.6[医药卫生—儿科]