氧化应激状态对骨生物材料理化性能及成骨效能的影响  

Research progress on the osteogenesis of bone biomaterials under oxidative stress

作　　者：黄静燕 王焱[1] Huang Jingyan;Wang Yan(Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University,Guangdong Provincal Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院,光华口腔医学院,广东省口腔医学重点实验室,广州510055

出　　处：《中华口腔医学研究杂志（电子版）》2020年第5期334-338,共5页Chinese Journal of Stomatological Research(Electronic Edition)

基　　金：广东省自然科学基金(2019A1515011842);广东省财政高水平医院建设专项资金(174⁃2018⁃XMZC⁃0001⁃03⁃0125/D⁃09)。

摘　　要：老年人及衰老相关性疾病、糖尿病等患病人群中骨植入材料周围的骨形成往往是受限的,而氧化应激是这类疾病的重要发病机制。近年来,骨生物材料在氧化应激微环境中的应用逐步受到关注,本文对氧化应激状态下骨生物材料成骨能力的研究进展进行综述,总结了骨生物材料与氧化应激微环境的相互作用,以加深对各病理状态下骨生物材料成骨机制的认识,同时为临床上选择合适的骨植入材料及设计新型的普适的骨生物材料提供依据和参考。The osteogenesis of bone biomaterials tends to be compromised among the population suffering from aging and aging related diseases as well as diabetes.It has been shown that such diseases are closely related to oxidative stress.In recent years,the application of bone biomaterials under oxidative stress microenvironment comes into focus.Upon reviewing the related publications,the osteogenesis of bone biomaterials,or the interplay between the biomaterials and the oxidative stress microenvironment was summarized.This review was expected to deepen the understanding on the osteogenic mechanism of bone biomaterials in pathological status,and play a reference role on the selection of appropriate bone biomaterials clinically and the design of novel universal biomaterials.

关 键 词：氧化应激 骨生物材料 成骨 

分 类 号：R318.08[医药卫生—生物医学工程]