高血压患者血清γ谷氨酰转移酶水平与冠状动脉钙化及狭窄的关系  

Relations of serumγ-glutamyl transferase level with coronary artery calcification and stenosis in patients with hypertension

作　　者：陈江红 张薇 郝启萌 曾广伟 党晶艺 CHEN Jianghong;ZHANG Wei;HAO Qimeng;ZENG Guangwei;DANG Jingyi(Department of Cardiology,Tangdu Hospital of Air Force Military Medical University,Xi’an,Shaanxi 710000,China)

机构地区：[1]空军军医大学唐都医院心内科,陕西省西安市710000

出　　处：《中国动脉硬化杂志》2020年第9期778-784,共7页Chinese Journal of Arteriosclerosis

基　　金：空军军医大学唐都医院骨干人才资助基金(2017-22)。

摘　　要：目的研究高血压患者血清γ谷氨酰转移酶(γ-GT)水平与冠状动脉钙化及狭窄的关系。方法选取2015年1月至2018年6月间145例高血压患者为高血压组,同时期60例血压正常人为血压正常组,对比两组患者血清γ-GT水平。根据高血压组患者冠状动脉螺旋CT造影结果及冠状动脉钙化评分(CACS)将其分为冠状动脉轻度钙化组、中度钙化组和重度钙化组;依照冠状动脉狭窄程度将其分为重度狭窄组、中度狭窄组和轻度狭窄组。比较各组血清γ-GT水平。结果高血压组患者血清γ-GT水平明显高于血压正常组(P<0.05);随着高血压等级的增加,患者血清γ-GT水平随之增加(P<0.05)。不同钙化程度患者血清γ-GT水平、CACS比较差异有统计学意义(P<0.05);随着钙化程度的加剧,γ-GT水平随之增加(P<0.05)。不同冠状动脉狭窄程度患者血清γ-GT水平、狭窄程度比较差异有统计学意义(P<0.05);随着冠状动脉狭窄程度的加剧,γ-GT水平随之增加(P<0.05)。血清γ-GT水平与CACS、冠状动脉狭窄程度呈正相关(P<0.05)。血清γ-GT是高血压患者冠状动脉狭窄或钙化发生的独立危险因素。结论高血压患者血清γ-GT水平明显升高,并且与冠状动脉钙化、狭窄程度显著相关。Aim To study the relations of serumγ-glutamyl transferase(γ-GT)level with coronary artery calcification and stenosis in patients with hypertension.Methods 145 patients with hypertension from January 2015 to June 2018 were selected as hypertension group,and 60 cases with normal blood pressure at the same period were set as normotensive group.The serumγ-GT level was compared between the two groups.According to the results of spiral CT coronary angiography and coronary artery calcification score(CACS),patients in hypertension group were divided into mild calcification group,moderate calcification group and severe calcification group;according to the degree of coronary stenosis,patients were divided into severe stenosis group,moderate stenosis group and mild stenosis group.The levels of serumγ-GT were compared in each group.Results The level of serumγ-GT in hypertension group was significantly higher than that in normotensive group(P<0.05);with the increase of hypertension grade,the level of serumγ-GT increased(P<0.05).The level of serumγ-GT and CACS score in patients with different degrees of calcification were significantly different(P<0.05);with the aggravation of calcification,the level ofγ-GT increased(P<0.05).There were significant differences in the level of serumγ-GT and the degree of stenosis in patients with different degrees of coronary artery stenosis(P<0.05);with the aggravation of the degree of coronary artery stenosis,the level ofγ-GT increased(P<0.05).The level of serumγ-GT was positively correlated with the score of CACS and the degree of coronary artery stenosis(P<0.05).Serumγ-GT was an independent risk factor for coronary artery stenosis or calcification in patients with hypertension.Conclusion The level of serumγ-GT is significantly increased in patients with hypertension,and and it is significantly related to the degree of coronary artery calcification and stenosis.

关 键 词：Γ谷氨酰转移酶 高血压 冠状动脉钙化 冠状动脉狭窄 

分 类 号：R544.1[医药卫生—心血管疾病]