Hetero diacylation of 1,1-diborylalkanes:Practical synthesis of 1,3-diketones  

作　　者：Liang-Hua Zou Min Fan Lu Wang Chao Liu 

机构地区：[1]Key Laboratory of Carbohydrate Chemistry and Biotechnology,Ministry of Education,School of Pharmaceutical Sciences,Jiangnan University,Wuxi 214122,China [2]State Key Laboratory for Oxo Synthesis and Selective Oxidation,Suzhou Research Institute of L1CP,Lanzhou Institute of Chemical Physics(LICP),Chinese Academy of Sciences,Lanzhou 730000,China

出　　处：《Chinese Chemical Letters》2020年第7期1911-1913,共3页中国化学快报（英文版）

基　　金：the National Natural Science Foundation of China(Nos.91745110,21673261,21603245,21703265,21872156,21802150,21773210 and 21603190);Natural Science Foundation of Jiangsu Province(Nos.BK20190002,BK20181194 and BK20180247);Support from the Young Elite Scientist Sponsorship Program by CAST(No.YESS20170217);the Youth Innovation Promotion Association CAS(No.2018458)。

摘　　要：An efficient protocol for the synthesis of asymmetric 1,3-diketones was reported through diacylation of1,1-diborylalkanes using two different acyl sources.In this transfo rmation,an enolate boron species was initially formed by introducing an acyl group,then it was trapped by another acyl group to form 1,3-diketone.This method not only provided the gateway to obtain a series of 1,3-diketones,but also afforded an operationally simple and efficient access to pyrazoles and isoxazoles.

关 键 词：1 1-Diborylalkanes Diacylation Enolate boron species Boron-stabilized carbanion intermediates 1 3-Diketones 

分 类 号：TQ224.2[化学工程—有机化工]