脂肪变性供肝保存技术进展  

Advances in the preservation of steatotic liver graft

作　　者：范林[1] 高芳[2] 付贞[1] 熊艳[1] 兰佳男[1] 叶啟发[1,3] Fan Lin;Gao Fang;Fu Zhen;Xiong Yan;Lan Jianan;Ye Qifa(Zhongnan Hospital of Wuhan University,Institute of Hepatobiliary Diseases of Wuhan University,Transplant Center of Wuhan University,Hubei Key Laboratory of Medical Technology on Transplantation,Wuhan 430071,China;Health Management Center,Binzhou People's Hospital,Binzhou 256610,China;The 3rd Xiangya Hospital of Central South University,Research Center of National Health Ministry on Transplantation Medicine Engineering and Technology,Changsha 410013,China)

机构地区：[1]武汉大学中南医院,武汉大学肝胆疾病研究院,武汉大学移植医学中心,移植医学技术湖北省重点实验室,武汉430071 [2]滨州市人民医院健康管理中心,滨州256610 [3]中南大学湘雅三医院卫生部移植医学工程技术研究中心,长沙410013

出　　处：《中华肝胆外科杂志》2020年第9期710-713,共4页Chinese Journal of Hepatobiliary Surgery

基　　金：中央高校基本科研业务费专项资金(2042018kf0062);武汉大学医学腾飞计划(TFLC2018003)。

摘　　要：为缓解供肝短缺、降低肝移植等待患者名单的死亡率,越来越多的研究集中在边缘供肝,如脂肪变性供肝。脂肪供肝耐受力差,常导致移植肝原发性无功能、早期功能不良、移植后血管和胆道并发症。部分研究表明,在严格筛选受者的前提下,中度和重度大泡型脂肪供肝可用于移植。本文主要总结各项技术,如静脉系统氧合、低温携氧灌注、亚常温机械灌注、常温机械灌注脂肪供肝保存效果,提升供肝质量以及脂肪变性供肝移植前景。More and more studies have been focusing on marginal donor livers,such as steatotic liver grafts,to alleviate donor shortage and reduce mortality from waiting lists.Poor tolerance of streatotic liver grafts often leads to primary graft nonfunction,early dysfunction,and postoperative vascular and biliary complications.Some studies have shown that moderate and severe macrosteatosis livers can be used for transplantation with rigorous selection of recipients.In this paper,techniques such as venous systemic oxygenated persufflation,hypothermic oxygenated perfusion,subnormothermic machine perfusion,normothermic machine perfusion,improved liver quality,and steatotic liver grafts transplantation were discussed.

关 键 词：肝移植 脂肪供肝 保存方式 机械灌注 

分 类 号：R657.3[医药卫生—外科学]