北京地区性传播疾病常见病原体感染现状分析  

Pathogen infection status of patients with sexually transmitted diseases in Beijing

作　　者：张立丽[1] 赵艳明[1] 佟瑄[1] 赵艳[1] 于艳华[1] 娄金丽[1] ZHANG Li-li;ZHAO Yan-ming;TONG Xuan;ZHAO Yan;YU Yan-hua;LUO Jin-li(Clinical Laboratory Center,Beijing You'an Hospital,Capital Medical University,Beijing 100069,CHINA)

机构地区：[1]首都医科大学附属北京佑安医院临检中心,北京100069

出　　处：《海南医学》2020年第19期2483-2486,共4页Hainan Medical Journal

摘　　要：目的了解北京地区性传播疾病常见病原体的感染现状,为临床诊疗及优生优育提供流行病学依据。方法收集2017年1月至2019年3月北京佑安医院皮肤性病门诊1927例样本的沙眼衣原体(CT)、解脲脲原体(UU)、淋病奈瑟菌(NG)、单纯疱疹病毒2型(HSV2)的核酸检测结果,并进行统计分析。结果1927份样本,阳性率最高为UU(39.0%),其次为CT(11.3%)、NG(5.0%),HSV2最低(2.4%);混合感染主要类型有CT+UU(5.1%)、UU+NG(1.3%)、CT+NG(1.1%);女性UU阳性率高于男性,男性NG阳性率高于女性,差异均有统计学意义(P<0.05);女性患者CT、UU以≤30岁阳性率最高,差异具有统计学意义(P<0.05);不同临床诊断组的CT、UU和NG阳性率比较差异均有统计学意义(P<0.05);梅毒、尖锐湿疣、HPV感染、阴道炎患者中UU与CT是主要病原体,尿道炎患者UU与NG为主要病原体;阴道炎患者≤30岁CT感染率最高;UU阳性组CT阳性率明显高于UU阴性组,NG阳性率则明显低于UU阴性组,而CT阳性组UU、NG阳性率明显高于CT阴性组,差异均有统计学意义(P<0.05)。结论性病患者UU检出率最高,有健康携带,治疗需结合临床;CT的检出率高于NG,女性CT与UU感染率呈年轻化;CT与UU,CT与NG易共感染,临床应进行多种病原联合检测,以防漏检,并加大筛查力度,防止无症状携带人群传播。Objective To investigate the infection status of common pathogens in patients with sexually transmitted diseases in Beijing,and to provide epidemiological evidence for clinical diagnosis and treatment.Methods Chlamydia trachomatis(CT),Ureaplasma urealyticum(UU),Neisseria gonorrhoeae(NG),Herpes simplex virus type 2(HSV2)nucleic acid test results of 1927 patients in the STD clinic of Beijing You'an Hospital from January 2017 to March 2019 were retrospectively analyzed.Results In 1927 cases,the positive rate of UU was the highest(39.0%),followed by CT(11.3%),NG(5%)and HSV2(2.4%).CT+UU(5.1%),UU+NG(1.3%),CT+NG(1.1%)were prone to coinfection.UU positive rate in females was higher than that of males(P<0.05),NG positive rate in males was higher than that of females(P<0.05),and CT,UU positive rate was the highest in female patients≤30 years old(P<0.05).Patients with different clinical symptoms were grouped,and the differences of positive rates of CT,UU and NG in different clinical symptom groups were statistically significant(P<0.05).UU and CT were the main pathogens in patients with syphilis,condyloma acuminatum,HPV infection,vaginitis.UU and NG were the main pathogens in urethritis.CT infection rate was highest in vaginitis patients≤30 years old.The CT positive rate of the UU positive group was significantly higher than that of the UU negative group(P<0.05),while the NG positive rate was significantly lower than that of the UU negative group(P<0.05).The positive rate of UU and NG in the CT positive group was significantly higher than that in the CT negative group(P<0.05).Conclusion The detection rate of UU is highest in STD patients,and the treatment needs to be combined with clinica practicel.The detection rate of CT is higher than NG.CT and UU infection rates of female patients show a trend of younger age.As CT and UU,CT and NG are prone to coinfection,combined detection of multiple pathogens should be carried out to prevent missed detection,and more efforts should be made in screening to prevent the spread of asy

关 键 词：北京地区 性传播疾病 沙眼衣原体 解脲脲原体 淋病奈瑟菌 单纯疱疹病毒2型 

分 类 号：R51[医药卫生—内科学]