维生素D联合锌硒宝治疗对RRTI患儿体内微量元素、免疫功能及炎症反应的影响  

Effects of vitamin D combined with XinXiBao(Zn/Se-enriched Protein Tablets)on trace elements,immune function,and inflammatory response in children with recurrent respiratory tract infection.

作　　者：郑文博 杨茹[1] ZHENG Wen-bo;YANG Ru(Department of Pediatrics,the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xiangyang 712000,Shaanxi,CHINA)

机构地区：[1]陕西中医药大学第二附属医院儿科,陕西咸阳712000

出　　处：《海南医学》2020年第19期2503-2506,共4页Hainan Medical Journal

摘　　要：目的探讨维生素D联合锌硒宝治疗对反复呼吸道感染(RRTI)患儿体内微量元素、免疫功能及炎症反应的影响。方法选取陕西中医药大学第二附属医院儿科2018年6月至2019年4月期间收治的RRTI患儿100例作为研究对象,将患儿按照随机数表法分为对照组和对照组各50例,对照组患儿采用常规治疗联合维生素D治疗,连续治疗20 d,停药10 d,以此为一个疗程,连续治疗两个疗程;观察组患儿在对照组治疗的基础上联合锌硒宝治疗,连续用药两个月。治疗结束后比较两组患儿的临床疗效,以及治疗前后的血清钙(Ca)、锌(Zn)水平、症状消失时间、营养状况指标、血清免疫功能和血清炎症因子水平。结果观察组患儿的治疗总有效率为94.0%,明显高于对照组的76.0%,差异有统计学意义(P<0.05);治疗后,观察组患儿的血清Ca为(2.2±0.3)mmol/L,与对照组的(2.3±0.3)mmol/L比较差异无统计学意义(P>0.05);治疗后,观察组患儿的血清Zn为(14.4±1.9)μmol/L,明显高于对照组的(11.6±1.5)μmol/L,差异有统计学意义(P<0.05);观察组患儿的咳嗽、哮喘、肺部啰音、退热等症状的消失时间分别为(4.3±0.5)d、(3.8±0.6)d、(3.9±0.3)d、(2.8±0.6)d,明显短于对照组的(5.5±0.6)d、(5.6±0.5)d、(5.7±0.3)d、(4.0±0.7)d,差异均有统计学意义(P<0.05);治疗后,观察组患儿的营养状况指标、血清免疫功能指标、血清炎症因子水平明显优于对照组,差异均有统计学意义(P<0.05)。结论维生素D联合锌硒宝治疗反复呼吸道感染患儿有利于改善患儿体内微量元素,提高免疫功能,抑制炎症反应,临床应用效果显著。Objective To explore the effect of vitamin D combined with XinXiBao(Zn/Se-enriched Protein Tablets)on trace elements,immune function,and inflammation in children with recurrent respiratory tract infection(RRTI).Methods A total of 100 children with RRTI who were admitted to the Department of Pediatrics,the Second Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine from Jun.2018 to Apr.2019 were selected as the research objects.The children were divided into a control group and a control group according to the random number table,with 50 children in each group.For example,children in the control group were treated with conventional treatment combined with vitamin D treatment for 2 courses(In one course,the drugs were given 20 days continuously,and then stopped for 10 days).On the basis of the treatment of the control group,the children in the observation group were treated with XinXiBao for 2 months continuously.After the treatment,the clinical efficacy of the two groups of children were compared,as well as the serum calcium(Ca)and zinc(Zn)levels before and after treatment,the time to symptom disappearance,nutritional status,serum immune function,Serum inflammatory factor levels.Results The total effective rate of treatment in the observation group was 94.0%,which was significantly higher than 76.0%in the control group(P<0.05).After treatment,the calcium(Ca)level of the observation group was(2.2±0.3)mmol/L,as compared with(2.3±0.3)mmol/L of the control group,and the difference was not statistically significant(P>0.05);the serum zinc(Zn)was(14.4±1.9)μmol/L,which was significantly higher than(11.6±1.5)μmol/L of the control group(P<0.05).The disappearance time of cough,asthma,pulmonary rales,and fever in the observation group were(4.3±0.5)d,(3.8±0.6)d,(3.9±0.3)d,(2.8±0.6)d,which was significantly shorter than(5.5±0.6)d,(5.6±0.5)d,(5.7±0.3)d,(4.0±0.7)d the control group(P<0.05);the nutritional status,serum immune function,and serum inflammatory factors of the children in the observat

关 键 词：反复呼吸道感染 维生素D 锌硒宝 免疫功能 炎症反应 微量元素 

分 类 号：R725.6[医药卫生—儿科]