丙型肝炎病毒对帕金森病影响的研究进展  

Research progress in influence of hepatitis C virus on Parkinson's disease

作　　者：曾昭豪 黄坤玉 汪露 李晓婷 毕伟[1,3] ZENG Zhao-hao;HUANG Kun-yu;WANG Lu;LI Xiao-ting;BI Wei(Department of Neurology,the First Affiliated Hospital of Jinan University,Guangzhou 510632,Guangdong,CHINA;College of Pharmacy,Jinan University,Guangzhou 510632,Guangdong,CHINA;Institute of Clinical Neuroscience,Jinan University,Guangzhou 510632,Guangdong,CHINA)

机构地区：[1]暨南大学附属第一医院神经内科,广东广州510632 [2]暨南大学药学院,广东广州510632 [3]暨南大学临床神经科学研究所,广东广州510632

出　　处：《海南医学》2020年第19期2552-2555,共4页Hainan Medical Journal

基　　金：国家自然科学基金青年基金(编号:81200930);暨南大学科研培育与创新基金跃升计划项目(编号:21617482)。

摘　　要：帕金森病(PD)是一种全球流行的神经退行性疾病,迄今为止,PD尚无药物根治,这主要源于PD发病机制中涉及多种因素。目前多数学者认为本病的发生发展与年龄、环境和遗传等因素之间的相互作用有关。近年来,越来越多的研究表明,病毒感染可能是PD的危险因素之一,多个流行病学研究的新数据表明PD与丙型肝炎病毒(HCV)感染之间可能存在关联。本文就丙型肝炎病毒与PD的关系及其可能致病机制的最新研究进行阐述。Parkinson's disease(PD)is a globally degenerative neurodegenerative disease.However,there is no cure for this disease due to the multiple factors involved in the pathogenesis of PD.At present,most scholars believe that this disease is related to interaction between age,environmental and genetic factors.In recent years,accumulating evidence has supported that viral infection is one of the possible risk factors for PD.Multiple epidemiological studies indicate that there may be a correlation between PD and hepatitis C virus(HCV)infection.This paper presents the latest research progress on the relationship between HCV and PD and its possible pathogenic mechanism.

关 键 词：丙型病毒肝炎 帕金森病 感染 抗HCV治疗 干扰素 发病机制 

分 类 号：R512.63[医药卫生—内科学]