光学相干层析成像技术原理及研究进展  

Optical coherence tomography:principles and recent developments

作　　者：陆冬筱 房文汇[1] 李玉瑶 李金华[1] 王笑军 LU Dong-xiao;FANG Wen-hui;LI Yu-yao;LI Jin-hua;WANG Xiao-jun(International Joint Research Center for Nanophotonics and Biophotonics,Nanophotonics and Biophotonics Key Laboratory of Jilin Province,School of Science,Changchun University of Science and Technology,Changchun 130022,China;School of Life Science and Technology,Changchun University of Science and Technology,Changchun 130022,China;Department of Physics,Georgia Southern University,Statesboro,Georgia 30460,USA)

机构地区：[1]长春理工大学纳米光子学与生物光子学国际联合研究中心,纳米光子学与生物光子学吉林省重点实验室理学院,吉林长春130022 [2]长春理工大学生命科学技术学院,吉林长春130022 [3]南乔治亚大学物理系,乔治亚州斯泰茨伯勒30460

出　　处：《中国光学》2020年第5期919-935,共17页Chinese Optics

基　　金：教育部“111”创新引智项目(No.D17017);国家自然科学基金资助项目(No.21703017,No.11604024);吉林省科技发展计划项目(No.20180519017JH,No.20190201181JC);吉林省国际科技合作项目(No.20190701029GH);吉林省教育厅项目(No.JJKH20190551KJ,No.JJKH20200730KJ);中国博士后科学基金(No.2019M651181);长春理工大学青年基金及科技创新基金(No.XQNJJ-2018-03,No.XJJLG-2018-01);东北师范大学紫外光发射材料与技术教育部重点实验室开放课题项目(No.130028908)。

摘　　要：光学相干层析成像(Optical Coherence Tomography,OCT)是一种基于低相干光干涉原理,利用样品背散/反射光与参考光相干的非接触非侵入性的新型成像技术,可提供具有微米级分辨率的一维深度,二维截面层析和三维立体的实时扫描图像。OCT技术具有非接触、无损伤、图像分辨率高且操作简单、便携等优点,主要应用于生物医学成像和诊断领域,弥补了共聚焦显微镜成像穿透深度低和超声波成像分辨率低的不足。目前,OCT技术已作为诊断视网膜疾病的临床标准,而且OCT技术结合内窥镜技术已成为临床上心血管及肠胃疾病诊断的重要工具,同时也为肌肉骨骼疾病,乃至癌症早期诊断、手术指导及术后康复提供依据。为了拓宽OCT技术的应用范围、提高医疗检测水平,研究人员正致力于增加OCT系统在生物组织中的穿透深度、提高系统的分辨率和信噪比、优化系统综合性能等方面的研究。本文论述了OCT系统的原理、分类,以及其在不同生物医学领域的应用及最新进展。Optical Coherence Tomography(OCT)is a new imaging technique that uses interference in low coherent light by measuring the delay and magnitude of backscattered or reflected signals from the sample.OCT technology can provide real-time structural information with one-dimensional depth and two-and threedimensional tomography at micron-scale resolution.Besides its high spatial resolution,OCT imaging is beneficial for its non-contact and non-invasive methodology.The system is also easy to operate and relatively portable.OCT technology is mainly applied in the biomedical imaging field for diagnoses,making up for the shortcomings of the low penetration depth in confocal microscopes and the low resolution in ultrasonic imaging.At present,OCT technology has been used as the clinical standard for the diagnosis of retinal diseases,and the combination of OCT technology and endoscope technology has become an important tool for the clinical diagnosis of cardiovascular and gastrointestinal diseases.It also provides references for early cancer diagnosis,surgical guidance and postoperative rehabilitation of musculoskeletal diseases.To broaden the application of OCT technology and improve its medical detection capabilities,researchers are committed to increasing the penetration depth of OCT imaging in biological tissue,improving the system's resolution and signal-to-noise ratio,and optimizing its overall performance.This review introduces the principle and classification of OCT systems,their applications and their recent progress in various biomedical fields.

关 键 词：光学相干层析成像 生物医学光学 近红外光 

分 类 号：O439[机械工程—光学工程]