异基因造血干细胞移植患者的四肢肌肉量及影响因素调查  

Muscle mass evaluation and influencing factors of sarcopenia in allogeneic hematopoietic stem cell transplantation patients

作　　者：张文坚[1] 马灵甫 王志敏[1] 莫文健[1] 周睿卿[1] Zhang Wenjian;Ma Lingfu;Wang Zhimin;Mo Wenjian;Zhou Ruiqing(Department of Hematology,Guangzhou First People’s Hospital,Guangzhou 510180,Guangdong Province,China)

机构地区：[1]广州市第一人民医院血液内科,广东省广州市510180

出　　处：《中国组织工程研究》2021年第13期1999-2004,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(81600147),项目负责人:周睿卿;广州市卫生健康科技项目一般引导项目(20201A011014),项目负责人:张文坚。

摘　　要：背景:肌肉组织在完成运动、保持体位、维持机体内环境稳态等方面发挥着重要作用,肌肉量的评估和干预有助于提升患者生存质量、缩短住院时间,成为近年的研究热点。目的:通过系统评估异基因造血干细胞移植患者的四肢肌肉量,探讨肌肉量下降的相关影响因素。方法:选取行异基因造血干细胞移植的146例患者为研究对象,采用一般资料调查表收集研究对象年龄、性别、文化程度等,采用生物电阻抗法评估肌肉量,同时收集研究对象体质量指数、上臂肌围、三头肌皮褶厚度、体脂率、预处理方案、抗胸腺细胞免疫球蛋白剂量、HLA配型、移植物来源、白蛋白、前清白蛋白、总蛋白和ECOG评分。以四肢矫正肌肉量为因变量,行t检验、卡方检验和二分类logistic回归分析。该研究通过广州市第一人民医院伦理委员会批准,所有患者同意参与此研究并签订知情同意书。结果与结论:①89例(60.9%)异基因造血干细胞移植患者出现肌肉量下降,其中男51例,女38例;通过与中国正常人群参照值比较发现,异基因造血干细胞移植患者表现为更低水平的肌肉量、上臂肌围和三头肌皮褶厚度,但体脂率显著上升,差异有显著性意义(P<0.05);②将患者分为低肌肉量组和正常肌肉量组,两组患者的体质量和体质量指数差异有显著性意义(P<0.05),但血清白蛋白、前清白蛋白和总蛋白等生化指标差异无显著性意义(P>0.05);③肌肉量单因素比较显示:体质量、体质量指数、预处理方案、ECOG评分差异有显著性意义(P<0.05);二分类logistic回归发现高体质量指数为异基因造血干细胞移植患者肌肉量的保护因素(OR=52.804,P<0.05),高ECOG评分为异基因造血干细胞移植患者肌肉量的危险因素(OR=0.458,P<0.05);④结果表明,异基因造血干细胞移植患者普遍存在四肢肌肉量下降,且肌肉量比白蛋白等血生化指标能更早地反映BACKGROUND:Muscle tissue plays an important role in completing exercise,maintaining body position and maintaining homeostasis in the body.Muscle quality assessment and intervention can help to improve the quality of life of patients and shorten the length of hospital stay,which has become a research hotspot in recent years.OBJECTIVE:To explore the related influencing factors of muscle mass decline by systematic assessment of limb muscle mass in patients undergoing allogeneic hematopoietic stem cell transplantation.METHODS:146 patients who underwent allogeneic hematopoietic stem cell transplantation were selected as the study subjects.The general information questionnaire was used to collect patients’age,sex,and education degree.Muscle mass was measured by bioelectrical impedance analysis.Patient’body mass index,arm muscle circumference,triceps skinfold thickness,body fat rate,conditioning regimen,antithymocyte globuin dose,HLA matching,graft source,albumin,prealbumin and total protein,and ECOG score were collected.The t test,chi square test and binary logistic regression analysis were used to analyze appendicular skeletal muscle.The study was approved by the Ethics Committee of Guangzhou First People’s Hospital.All patients agreed to participate in the study and signed informed consent.RESULTS AND CONCLUSION:(1)Muscle mass loss was observed in 89 patients(60.9%)of allogeneic hematopoietic stem cell transplantation,including 51 males and 38 females.Compared with the reference values of the Chinese normal population,it was found that allogeneic hematopoietic stem cell transplantation patients showed lower levels of muscle mass,arm muscle circumference and triceps skinfold thickness,but body fat rate increased significantly,with statistically significant differences(P<0.05).(2)The patients were divided into the low muscle mass group and the normal muscle mass group.The differences in body weight and body mass index between the two groups were statistically significant(P<0.05),but the differences in biochemical

关 键 词：干细胞 异基因 造血干细胞 干细胞移植 四肢 肌肉量 肌少症 人体成分 影响因素 

分 类 号：R457[医药卫生—治疗学] R394.2[医药卫生—临床医学]