Synthesis and Biological Evaluation of Novel Anthranilic Diamides Containing N-H/CH3-1H-Pyrazoie  

作　　者：ZHANG Xiulan ZHANG Huan LIU Jingbo XIONG Lixia LI Zhengming 

机构地区：[1]College of Science,Tianjin University of Science&Technology,Tianjin 300457,P.R.China [2]State Key Laboratory of Elemento-Organic Chemistry,Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,P.R.China

出　　处：《Chemical Research in Chinese Universities》2020年第5期829-834,共6页高等学校化学研究（英文版）

基　　金：Supported by the Scientific Research Program of Tianjin Municipal Education Commission,China(No.2018KJ114).

摘　　要：In order to systematically study the structure-activity relationship of anthranilic diamides and develop insecticides with simple structure and high efficiency,a series of novel anthranilic diamides containing N-H/CH3-lH-pyrazole was designed and synthesized.Their chemical structures were characterized by NMR spec-tra,high resolution mass spectrometry(HRMS)or 13C NMR spectra.The preliminary bioassay results indicated that all title compounds displayed moderate insecticidal activity against oriental armyworm(Mythinina separata)at 200 mg/L and ftmgicidal activities against six kinds of fungi at 50 mg/L,especially compound 5i showed 50%insecticidal activity at 25 mg/L.In addition,some compounds exhibited certain antitumor activities.It was demonstrated that the introduction of CH3 group into pyrazole ring was superior to H for the insecticidal activity.

关 键 词：Anthranilic dianiide Insecticidal activity Fungicidal activity Antitumor activity 

分 类 号：O62[理学—有机化学]