Ball-milling Synthesis of Tetrahydroquinolines via 'One-pot' Three-component Diels-Alder Reaction Catalyzed by Phosphotungstic Acid  

作　　者：WANG Zeyou SHEN Guodong HUANG Xianqiang GONG Shuwen YANG Bingchuan SUN Zhenzhen ZHANG Zuhao LIU Wanxing 

机构地区：[1]School of Chemistry and Chemical Engineering,Liaocheng University,Liaocheng 252000,P.R.China [2]Department of Chemistry,Liaocheng Chemical Institute of Industrial Science,Liaocheng 252000,P.R.China

出　　处：《Chemical Research in Chinese Universities》2020年第5期835-842,共8页高等学校化学研究（英文版）

基　　金：Supported by the Natural Science Foundation of Shandong Province,China(Nos.ZR2019QB022,ZR2019MB043).

摘　　要：We reported an economic and practical ball-milling method for the synthesis of tetrahvdroquinoline derivatives via a wone-pot"three-component Diels-Alder reaction of anilines,aldehydes and alkenes catalyzed by phos-photungstic acid at room temperature.For this reaction,a simple 'one-pot'ball-milling operation was conducted,readily available starting materials were employed,'one-pot'conditions were applied,and the most important was to use inexpensive and environmentally friendly catalyst phosphotungstic acid.Various tetrahvdroquinolines,which might be potentially applicable in the pharmaceutical and biochemical areas,were conveniently synthesized in moderate to excellent yields.

关 键 词：Ball-milling Diels-Alder reaction Phosphotungstic acid Tetraliydroquinoline 

分 类 号：O62[理学—有机化学]