Green and Efficient Synthesis of 3-Pyrazolyl Indoles in Water  

作　　者：ZHAO Yanhui YU Haifeng LIAO Peiqiu WANG Wenju 

机构地区：[1]College qf Chemistry,Baicheng Normal University,Baicheng 137000,P.R.China [2]Jilin Province Key Laboratory of Organic Functional Molecular Design&Synthesis,Faculty of Chemistry,Northeast Normal University,Changchun 130024,P.R.China

出　　处：《Chemical Research in Chinese Universities》2020年第5期847-852,共6页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.20902010);the Foundation of Science and Technology Research Projects of the 13th Five-year Plan of Jilin Provincial Department of Education,China(No,2016037).

摘　　要：A green and efficient synthesis of 3-pyrazolyl indoles was developed by the eye 1 ocondensation reactionof β-ethylthio-β-indolyl-α,β-unsaturated ketones with semi carbazide hydrochloride as hydrazine equivalent in thepresence of 3 equiv. of PEG400(la/PEG mole ratio of 1:3) in reflux water. This procedure did not require toxichydrazine and product purification, eliminating the use of toxic liquid chemicals.

关 键 词：3-Pyrazolyl indole Green synthesis Semicarbazide hydrochloride Polyethylene glycol Hydrazine equivalent 

分 类 号：O62[理学—有机化学]