Design, Synthesis and Biological Activities of Novel N-Aryl-1H-pyrazole-5-carboxylate Derivatives  

作　　者：ZHANG Xiulan ZHANG Huan MA Jinlong YU Shujing LI Zhcngming 

机构地区：[1]College of Science,Tianjin University of Science&Technology,Tianjin 300457,P.R.China [2]State Key Laboratory of Elemento-Organic Chemistry,Institute of Elemento-Organic Chemistry,Nankai University,Tianjin 300071,P.R.China

出　　处：《Chemical Research in Chinese Universities》2020年第5期853-858,共6页高等学校化学研究（英文版）

基　　金：Supported by the Scientific Research Program of Tianjin Municipal Education Commission,China(No.2018KJ114).

摘　　要：In an attempt to search for potent fungicide,a series of novel N-ary 1-1H-pyrazole-5-carboxylate derivatives was designed and synthesized.Tlieir chemical structures were characterized by 1H NMR spectra and high reso・lution mass spectrometry(HRMS).The preliminary bioassay results indicated that some target compounds displayed better fungicidal activities against certain fungi at 50μg/mL or favorable antitumor activities at 5 μg/mL compared with chlorothalonil and 5-fluorouracil,respectively.The structure-activity relationship demonstrated that the introduction of ester group and amide bond was favorable to the improvement of activities against Physalospora pin cola and Phytophthora capsici.

关 键 词：N-Aryl-1H-pyTazole-5-carboxylate Fungicidal activity Antitumor activity 

分 类 号：O62[理学—有机化学]