Preparation and Characterization of CaO/ZnO Core-shell Structured Nanoparticles  

作　　者：WANG Lili LIU Yanan PENG Xiaoxing SUN Yuanqing LIU Xiaohua LIU Huimin LIN Quan SUN Hongchen YANG Bai LI Xiangwei 

机构地区：[1]School of Stomatology,Jilin University,Changchun 130021,P.R.China [2]Hospital Attached to Changchun University of Chinese Medicine,Changchun 130041,P.R.China [3]State Key Laboratory of Supramol ecular Structure and Materials,Jilin University,Changchun 130012,P.R.China [4]Department of Biomedical Sciences,Texas A&M University,College of Dentistry,Dallas,TX 75246,USA

出　　处：《Chemical Research in Chinese Universities》2020年第5期970-975,共6页高等学校化学研究（英文版）

基　　金：Supported by the Jilin Provincial Health Department Research Projects,China(No.2017J065);the Jilin Provincial Education Department Research Projects,China(No.JJKII20180229KJ).

摘　　要：Residual bacteria and microleakage in a complicated root canal can often result in reinfection of the periapical tissues.To promote the antibacterial and sealing eftects of a root canal filling,core-shell structured CaO/ZnO nanospheres were synthesized using a precipitation method based on a traditional root canal sealer,zinc oxide-eugenol(ZOE).The obtained CaO/ZnO particles had a size of 80—90 nm and a core-shell structure.The film thickness,flow rate,pH,and calcium ion release of the core-shell structured CaO/ZnO nanospheres-eugenol paste were tested.The pH and calcium ion release results showed a slight increase in the prepared nanospheres,with a flow rate of 24.22 mm and a formed film thickness of 30 pm,which are basically consistent with ISO 6876:2001 standards(regarding dental root canal sealing materials).Cytotoxicity tests showed that the cytocompatibility of the CaO/ZnO nanospheres-eugenol paste was much higher than that of the ZOE or iRoot SP groups(P<0.05).A comparison of the sealing ability and antibacterial activity showed that the core-shell structured CaO/ZnO nano spheres-eugenol paste had significantly better effects than the ZOE and iRoot SP sealers(P<0.05).The core-shell structured CaO/ZnO nano sphere paste displayed excellent sealing and antibacterial properties,and it has promising application potential in endodontics.

关 键 词：CAO ZNO Antibacterial activity Core-shell stnictured naiiosphere MICROLEAKAGE 

分 类 号：TB383[一般工业技术—材料科学与工程]