子痫前期患者脐血血栓弹力图的特点分析  

作　　者：廖义鸿 王硕石[1] 

机构地区：[1]暨南大学第二临床医学院深圳市人民医院妇产科,广东深圳518002

出　　处：《临床医药文献电子杂志》2020年第58期11-13,共3页Electronic Journal of Clinical Medical Literature

基　　金：深圳市卫生计生系统科研项目(201505003)。

摘　　要：目的通过分析子痫前期患者的脐血血栓弹力图及凝血特点,探讨子痫前期患者的胎儿胎盘循环的特点及发病机制。方法抽取子痫前期组及对照组分娩后的脐静脉血,行凝血四项、D-二聚体、血栓弹力图检测,脐动脉血做血气分析。结果子痫前期组的凝血四项APPT明显延长,PT、TT、FIB及D-二聚体差异无显著性,血栓弹力图K值显著增大,MA显著减少,R值增大,α角较小,CI负值,但无显著性差异。脐动脉血血气分析,子痫前期组氧分压显著低于对照组。结论子痫前期患者脐静脉血存在低凝状态,脐动脉血存在低氧,可能为母胎界面微血栓形成引起消耗性低凝,进而影响母胎的供氧,造成胎儿不良结局。Objective To analyze the umbilical cord thromboelasticity and coagulation characteristics of preeclampsia patients and to explore the characteristics and pathogenesis of fetal placental circulation in patients with preeclampsia.Methods Umbilical venous blood of the preeclampsia group and the control group after delivery were examined.The coagulation,D-dimer,thromboelastography were detected.Umbilical arterial blood was analyzed for blood gas.Results APPTs in the preeclampsia group were significantly prolonged.The differences in PT,TT,FIB,and D-dimer were not significant.The K value of the thromboelastogram increased significantly,the MA value decreased significantly.The R value increased,theαangle Smaller and negative CI have no significant difference.Blood gas analysis of cord blood showed that the partial pressure of oxygen in the preeclampsia group was significantly lower than that in the control group.Conclusion Hypocoagulation and umbilical arterial blood hypoxemia in preeclampsia patients may cause wasting hypocoagulation due to microthrombosis at the maternal-fetal interface,which in turn affects the maternal-fetal oxygen supply and causes adverse fetal outcomes.

关 键 词：子痫前期 凝血状态 血栓弹力图 血气分析 

分 类 号：R714.25[医药卫生—妇产科学]