基于脑-肠轴探讨消化疾病和失眠共病的应用展望  

Application perspectives of digestive diseases and insomnia comorbidity based on brain-gut axis

作　　者：侯理伟 荣培晶[2] 魏玮[3] 方继良[4] 王瑜 赵斌 HOU Li-wei;RONG Pei-jing;WEI Wei;FANG Ji-liang;WANG Yu;ZHAO Bin(Institute of Acupuncture and Moxibustion,China Academy of Chinese Medical Sciences,Beijing 100700,China;Wangjing Hospital of China Academy of Chinese Medical Sciences,Beijing 100102,China;Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China)

机构地区：[1]中国中医科学院针灸研究所,北京100700 [2]中国中医科学院针灸研究所机能室,北京100700 [3]中国中医科学院望京医院,北京100102 [4]中国中医科学院广安门医院,北京100053

出　　处：《中华中医药杂志》2020年第9期4541-4544,共4页China Journal of Traditional Chinese Medicine and Pharmacy

基　　金：国家自然科学基金面上项目(No.81473780,No.81774433);国家自然科学基金重点国际合作研究项目(No.81820108033);科技部国家重点研发计划中医药现代化研究项目(No.2018YFC1705802);中国中医科学院针灸研究所基本科研业务费自主选题项目(No.ZZ201915009)。

摘　　要：失眠是临床常见病、难治病。目前现代医学治疗失眠主要采用药物疗法、认知行为疗法,但药物治疗具有成瘾性、不良反应多,认知行为治疗缺乏专业规范培训,疗效不稳定,亟需其他可行治疗方法。中医认为"胃不和则卧不安",从脾胃辨证论治失眠具有良好的效果。对共病性失眠的现代科学内涵深入研究发现,失眠发病机制可能和消化系统疾病相关。现代医学从脑-肠轴角度探索消化系统疾病发病机制成为研究热点,文章以脑-肠轴为立足点阐述消化系统疾病和失眠共病的机制,探索安全有效的替代治疗方法,为失眠和消化系统疾病共病的诊治提供新思路。Insomnia is one refractory common clinical disease.Western medicine treatment for insomnia includes drug therapy and cognitive behavioral therapy.The commonly used drugs are not sufficient,for there are some adverse drug reactions or addiction,cognitive behavioral therapy lacks professional training as well,so it is necessary to find other feasible treatment methods.Clinically there are more common digestive system disease and insomnia comorbidity.Then,Chinese herb medicine stresses that‘stomach disharmony is lying uneasiness’,clinical treatment of insomnia from the spleen and stomach system that based on the classical theory has a good effect.Extend its scientific connotation to be able to discover,insomnia combined with digestive system disease have interlinked pathogenesis diseases.At present,it has become a research hotspot to explore the pathogenesis of gastrointestinal diseases in western medicine from the perspective of brain-gut axis.Based on the brain-gut axis,this paper makes an in-depth exploration and elaboration of the mechanism of digestive diseases combined with insomnia,reviewing and exploring safer and more effective alternative therapies,to provide new ideas for insomnia and its comorbidity with digestive diseases.

关 键 词：消化疾病 脑-肠轴 共病性失眠 替代治疗 

分 类 号：R256.23[医药卫生—中医内科学] R259[医药卫生—中医学]