AMH检测对多囊卵巢综合征的诊断价值  

Diagnostic value of AMH detection in polycystic ovary syndrome

作　　者：蔡小华 蔡柳洪[1] 欧建平[1] 李涛[1] 邢卫杰[1] 朱洁茹[1] CAI Xiaohua;CAI Liuhong;OU Jianping;LI Tao;XING Weijie;ZHU Jieru(Reproductive Medicine Center,Third Affiliated Hospital,Sun Yatsen University,Guangzhou,Guangdong 510630,China)

机构地区：[1]中山大学附属第三医院生殖医学中心,广东广州510630

出　　处：《检验医学与临床》2020年第20期2961-2963,2967,共4页Laboratory Medicine and Clinic

摘　　要：目的评估抗缪勒管激素(AMH)检测对多囊卵巢综合征(PCOS)的诊断价值。方法纳入研究对象169例,分为PCOS组93例,对照组76例,检测血清中的AMH、卵泡刺激素(FSH)、促黄体生成素(LH)、泌乳素(PRL)、雌二醇(E 2)和睾酮(T)水平。比较两组患者的血清激素水平及LH/FSH,通过受试者工作特征(ROC)曲线及曲线下面积(AUC)比较各指标对PCOS的诊断效能,分析血清AMH水平与其他诊断指标的相关性。结果(1)PCOS组的AMH、LH、T水平和LH/FSH均显著高于对照组(P<0.05),FSH、PRL、E 2水平差异无统计学意义(P>0.05)。(2)PCOS患者AMH水平与LH、T和LH/FSH呈显著正相关(r=0.573、0.599、0.662,P<0.05)。(3)各指标的诊断价值方面,AMH的AUC显著高于LH和T(P<0.05),与LH/FSH的AUC比较,差异无统计学意义(P>0.05),AMH预测PCOS的最佳临界值为8.07 ng/mL。结论AMH检测对PCOS有辅助诊断价值。Objective To evaluate the diagnostic value of anti-Mullerian hormone(AMH)detection in polycystic ovary syndrome(PCOS).Methods A total of 169 cases were included,including 93 cases in the PCOS group and 76 cases in the control group.The levels of serum AMH,follicle stimulating hormone(FSH),luteinizing hormone(LH),prolactin(PRL),estradiol(E 2)and testosterone(T)were measured.The serum hormone levels and LH/FSH were compared between the two groups,the diagnostic efficiency of each index for PCOS was compared by the area under the receiver operating characteristic curve(ROC-AUC),and the correlation between serum AMH level and other diagnostic indexes was analyzed.Results(1)The AMH,LH and T levels and LH/FSH ratio in the PCOS group were significantly higher than those in the control group(P<0.05).There was no statistically significant difference in the levels of FSH,PRL and E 2(P>0.05).(2)The AMH level in the patients with PCOS had significantly positive correlation with LH,T and LH/FSH ratio(r=0.573,0.599 and 0.662,P<0.05).(3)In the diagnostic value of each index,AUC of AMH was significantly higher than that of LH and T(P<0.05),and its comparison with AUC of LH/FSH showed no statistical difference(P>0.05).The best cut-off value of AMH for predicting PCOS was 8.07 ng/mL.Conclusion AMH has the assisted diagnostic value for PCOS.

关 键 词：抗缪勒管激素 多囊卵巢综合征 诊断效能 

分 类 号：R446.112[医药卫生—诊断学]