玻璃酸钠关节腔内注射治疗膝骨关节炎患者的临床效果  

Clinical effect of intra-articular injection of Sodium Hyaluronate in patients with knee osteoarthritis

作　　者：李瑾[1] 饶海军 林学扬[1] 杨建华 LI Jin;RAO Hai-jun;LIN Xue-yang;YANG Jian-hua(Department of Orthopedics,People′s Hospital of Longgang District in Shenzhen City,Guangdong Province,Shenzhen 518000,China)

机构地区：[1]深圳市龙岗区人民医院骨科,广东深圳518000

出　　处：《中国当代医药》2020年第28期127-130,共4页China Modern Medicine

基　　金：广东省深圳市医疗卫生科技计划项目(LGKCYLWS2018000084)。

摘　　要：目的探讨运用玻璃酸钠关节腔内注射治疗膝骨关节炎患者的临床效果。方法选取2018年1月~2019年12月我院骨科收治的107例膝骨关节炎患者作为研究对象,以随机抽签法分为试验组(57例)及对照组(50例)。试验组患者给予膝关节腔内注射玻璃酸钠,对照组患者给予口服盐酸氨基葡萄糖胶囊。观察比较两组患者的病情严重程度、西安大略和麦克马斯特大学(WOMAC)骨关节炎指数评分、滑膜厚度、炎症水平、视觉模拟量表(VAS)疼痛评分及治疗效果。结果治疗前两组患者的病情严重程度、WOMAC骨关节炎指数评分、滑膜厚度、静脉血肿瘤坏死因子-α(TNF-α)水平、VAS疼痛评分比较,差异无统计学意义(P>0.05);治疗后,两组患者的病情严重程度、WOMAC骨关节炎指数评分、滑膜厚度、静脉血TNF-α水平、VAS疼痛评分均低于治疗前,差异有统计学意义(P<0.05);治疗后,试验组患者的病情严重程度、WOMAC骨关节炎指数评分、滑膜厚度、静脉血TNF-α水平、VAS疼痛评分均低于对照组,差异有统计学意义(P<0.05)。试验组患者的治疗总有效率(94.74%)高于对照组(82.00%),差异有统计学意义(P<0.01)。结论膝关节腔内注射玻璃酸钠可以明显改善膝骨关节炎患者的症状,减轻疾病严重程度,减少疼痛,下调炎症反应,降低滑膜厚度,治疗效果较好。Objective To explore the clinical effect of intra-articular injection of Sodium Hyaluronate in patients with knee osteoarthritis.Methods A total of 107 patients with knee osteoarthritis admitted to our hospital from January 2018 to December 2019 were selected as subjects and divided into the experimental group(57 cases)and the control group(50 cases)by random lottery method.The experimental group was given intra-articular injection of Sodium Hyaluronate,the control group was given oral Glucosamine Hydrochloride Capsules.The severity of the disease,Western Ontario and McMaster University(WOMAC)osteoarthritis index score,the synovial thickness,the level of venous tumor necrosis factor-α(TNF-α),the visual analogue scale(VAS)pain score and the efficacy of the treatment were compared between the two groups.Results There were no statistically significant differences in severity of disease,WOMAC osteoarthritis index score,the synovial thickness,the level of venous TNF-αand VAS score between the two groups before and after treatment(P>0.05).After treatment,the severity of disease,WOMAC osteoarthritis index score,the synovial thickness,the level of venous TNF-αand VAS score of experimental group were lower than those of the control group,and the differences were statistically significant(P<0.05).The severity of disease,WOMAC osteoarthritis index score,the synovial thickness,the level of venous TNF-αand VAS score of the two groups after treatment were lower than those before treatment,and the differences were statistically significant(P<0.05).The total effective rate in the experimental group(94.74%)was higher than that in the control group(82.00%),and the difference was statistically significant(P<0.01).Conclusion Intra-articular injection of Sodium Hyaluronate can obviously improve the symptoms of patients with knee osteoarthritis,alleviate the severity of disease,reduce pain,inflammation reaction and the thickness of synovial and has a good therapeutic effect.

关 键 词：玻璃酸钠 关节腔内注射 膝骨关节炎 滑膜厚度 西安大略和麦克马斯特大学骨关节炎指数评分 

分 类 号：R684.3[医药卫生—骨科学]