Fe3O4@ZIF-67分散微固相萃取法测定水中青霉素类抗生素  

Determination of penicillins in water by Fe3O4@ZIF-67 dispersive micro-solid phase extraction

作　　者：李彦妮 胡艳云 陈文军[1] 金忠秀[1] Li Yanni;Hu Yanyun;Chen Wenjun(Dept of Nutrion and Food Hlygiene,School of Public Health,Anhui Medical University,Hefei 230032;Hefei National Laboratory for Physical Sciences at Microscale,University of Science and Technology of China,Hefei 230026)

机构地区：[1]安徽医科大学公共卫生学院营养与食品卫生学系,合肥230032 [2]中国科学技术大学合肥国家微尺度材料科学研究中心,合肥230026

出　　处：《安徽医科大学学报》2020年第11期1806-1810,共5页Acta Universitatis Medicinalis Anhui

基　　金：国家自然科学基金(编号:21607003);安徽医科大学博士科研基金(编号:XJ201622)。

摘　　要：建立了Fe3O4@ZIF-67磁性分散微固相萃取(DMSPE)结合液相色谱串联质谱法(LC-MS/MS)测定水样中6种青霉素类抗生素(PCs)残留的方法。在最佳萃取条件下,水样中6种PCs的检测限为0.01~0.06μg/L,定量限为0.03~0.19μg/L;在0.1、1.0、10.0μg/L三个添加浓度水平下,6种PCs在河水和养殖水样中的添加回收率分别为79.2%~96.6%和75.9%~94.8%;河水和养殖水体中的6种PCs的基质效应分别为90.3%~102.2%和89.6%~105.6%。Fe3O4@ZIF-67具有高效吸附PCs的能力,结合LC-MS/MS可实现对水样中6种PCs同时快速检测。Established Fe3O4@ZIF-67 magnetic dispersive micro-solid phase extraction(DMSPE)combined with liquid chromatography-tandem mass spectrometry(LC-MS/MS)to determine 6 penicillins(PCs)in water samples residual method.Under the optimal extraction conditions,the detection limit of 6 PCs in water samples was 0.01~0.06μg/L,and the limit of quantification was 0.03~0.19μg/L;under the three concentration levels of 0.1,1.0,10.0μg/L,the recovery rates of the 6 PCs in river water and aquaculture water samples were 79.2%~96.6%and 75.9%~94.8%,respectively;the matrix effect of the six PCs in river water and aquaculture water were 90.3%~102.2%and 89.6%~105.6%.Fe3O4@ZIF-67 has the ability to efficiently adsorb PCs.Combined with LC-MS/MS,it can realize the simultaneous rapid detection of 6 PCs in water samples.

关 键 词：Fe3O4@ZIF-67 LC-MS/MS 磁性分散微固相萃取 青霉素 

分 类 号：O647.3[理学—物理化学]