复苏周期中不同发育天数双囊胚移植临床结局分析  

Analysis of clinical outcomes of double blastocysts transfer with different development days in resuscitation cycles

作　　者：穆耀琴 丁丁[1,2,3,4,5] 魏兆莲 曹云霞[1,2,3,4,5] 章志国[1,2,3,4,5] 周平 Mu Yaoqin;Ding Ding;Wei Zhaolian(Reproductine Medicine Center,Dept of Obstetrics and Gynecology,The First Afiliated Hospital of Anhui Medical University,Hefei 230022;NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract,Anhui Medical University,Hefei 230032;Key Laboratory of Population Health Across Life Cycle,Anhui Medical University,Ministry of Education of the People's Republic China,Hefei 230032;Anhui Province Key Laboratory of Reproductive Health and Genetics,Hefei 230032;Biopreservation and Arificial Organs,Anhui Provincial Engineering Research Center,Anhui Medical University,Hefei 230032)

机构地区：[1]安徽医科大学第一附属医院妇产科,合肥230022 [2]国家卫生健康委配子及生殖道异常研究重点实验室,合肥230032 [3]出生人口健康教育部重点实验室,合肥230032 [4]生殖健康与遗传安徽省重点实验室,合肥230032 [5]安徽省生命资源保存与人工器官工程技术研究中心(安徽医科大学),合肥230032

出　　处：《安徽医科大学学报》2020年第10期1610-1613,共4页Acta Universitatis Medicinalis Anhui

基　　金：国家重点研发计划生殖健康及重大出生缺陷防控研究重点专项(编号:2017YFC1002004);中国医学科学院中央级公益性科研院所基本科研业务费专项(编号:2019PT310002);安徽高校协同创新项目(编号:GXXT-2019-044)。

摘　　要：目的比较玻璃化冻融后双D5、D5+D6与双D6囊胚移植的临床结局,同时探究复苏周期中D5+D6囊胚移植方案的有效性和安全性。方法回顾性分析和比较行体外受精/卵胞质内单精子显微注射技术-胚胎移植(IVF/ICSI-ET)双囊胚移植的2180个周期的临床数据。按照移植胚胎发育天数分为3组:双D5组,1201个周期;D5+D6组,205个周期;双D6组,774个周期。结果D5+D6组的生化妊娠率、临床妊娠率及多胎妊娠率均高于双D6组(P<0.001),且低于双D5组(P<0.001)。双D5组的早期流产率高于D5+D6组和双D6组(P>0.05,P<0.05)。D5+D6组的异位妊娠率低于双D5组和双D6组,但差异无统计学意义(P>0.05)。结论D5+D6囊胚移植作为一种新的移植方案可以获得较好的临床结局。Objective To compare the clinical outcomes of double D5, D5+D6 and double D6 blastocysts transfer, meanwhile, explore the effectiveness and safety of D5+D6 blastocysts transfer protocol.Methods A retrospective analysis of 2 180 cycles of in vitro fertilization/intracytoplasmic sperm injection-embryo transfer(IVF/ICSI-ET) in reproductive medicine center of our hospital. All cycles were divided into three groups in accordance with the different development days of blastocysts: double D5 group(n=1 201), D5+D6 group(n=205) and double D6 group(n=774).Results The biochemical pregnancy rates, clinical pregnancy rates and multiple pregnancy rates in the D5+D6 group were higher than those in the double D6 group(P<0.001), and lower than those in the double D5 group(P<0.001). Double D5 group had higher early pregnancy loss rate compared with D5+D6 group and double D6 group(P>0.05, P<0.05, respectively). The ectopic pregnancy rate in the D5+D6 group was lower than that in the double D5 group and the double D6 group, but there was no significant difference(P>0.05).Conclusion D5+D6 blastocysts transfer as a new protocol can obtain good clinical outcomes.

关 键 词：双D5囊胚 D5+D6囊胚 双D6囊胚 冻融囊胚移植 临床结局 

分 类 号：R714.8[医药卫生—妇产科学]